ID A0A0D9QRV1_PLAFR Unreviewed; 3322 AA.
AC A0A0D9QRV1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AK88_00536 {ECO:0000313|EMBL:KJP89825.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP89825.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP89825.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ001648; KJP89825.1; -; Genomic_DNA.
DR RefSeq; XP_012333607.1; XM_012478184.1.
DR EnsemblProtists; KJP89825; KJP89825; AK88_00536.
DR GeneID; 24265850; -.
DR VEuPathDB; PlasmoDB:AK88_00536; -.
DR OMA; NFCDIVG; -.
DR OrthoDB; 228292at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 5.
DR Gene3D; 2.60.120.10; Jelly Rolls; 5.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR11635:SF168; CAMP PROTEIN KINASE REGULATORY CHAIN; 1.
DR PANTHER; PTHR11635; CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR SMART; SM00100; cNMP; 4.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 5.
DR PROSITE; PS50042; CNMP_BINDING_3; 5.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842}.
FT DOMAIN 1387..1422
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1913..2015
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2164..2271
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2317..2440
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2942..3046
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 3069..3175
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 643..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1576..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2518..2558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2610..2691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3226..3322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1090
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2530..2551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2610..2647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2654..2668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2669..2689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3226..3249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3260..3314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3322 AA; 386468 MW; 10146B0DEA07B226 CRC64;
MRKENMDDLE SGAIENIHHY LKECLDRNNF KVNPAGAQRD INDVSLIHSS LKKYIVRLAN
INNFIKQENY FLKKTNEQLV RKCNERDACG FYKNEKGTHR VHRRHGPLET HGTHTMCMNE
MHKLSDENEF IKYKYEQMLR QNLSLQENNA QLNNTLLNRD KYEPHTNEGN GKLKIENGFL
SQSLNHLLPH QEEGRNMLRS RNEKGGETKP AEVNYMTFEG KINRILKCTK ILEEILDILN
SNLKYDEPLM FQKKMNLMEV EKEQLIKQND FLKEKILQIE TFILNDPFLV EKFNFFYDST
SINIDPCIRD NIELYKNNSI KRMFHNLRCS QSTNADLKQQ LLSEKKKSHI YQSYIYDMRE
KLKDDLNELF SLNRDQNMNY HNLNGCDDSI RHFSEKDSSS PWNIFYEAGN NGDELVSRKE
HQKYYNYLSD FSTPNFYRMC KINSSKIDHN EQMLTQSWNR IRELDQDAGC FEKRKYEQIF
RQDEHDASVA ELEGDMQNEV YYFRIKKLIS MRKQELDRMM QSGGRQLASQ KKKEDSNKLK
NELYLNRVEY KEALREWLRG QEQKLQTSDN PRNNLLCGNK NIDQLNLYIK RKIIYQFVKY
KHIYEYFVQN ESVCKNQISK DKFINFFNKH ILNVQHGDTA QCANKGTPGN GKRGVTKSCQ
KGKRLHEDEA NQKRGSAYVE EDSTQYHDVT LEDDARRGSH HSEESTLRSD HPGEKRAEAT
GSKEGDATRE KKRESKRERQ REIKEVQEKQ RKIKAEMENE KLRKMERKKQ RKMEKEKQRK
MEREKQREEE RARKVQVERT SQVDGDPPTN ENQAGEEENQ NHREMEIEME IEPSDKSQEE
NMKKENLKKN DDISEKFYMR EEHPRRHDSS LGVLINTIKN IDKNKMEKNM TSKNVEGLFS
PTHSMNERSR SSLIGESPQK ERRASNVSKK DSSQGSVESI KSSKSFDVEP TEGKMNQSEE
EANDREEFSL GHAESDATNS VDAEDGKKKQ FFNLSSEPEK EDHMGGEDNP EEDINQGGGE
MRIGAVAQVS ERLSVEDKII VSGSVALDDI RRINTMRGAG ALELIQPEGD AQMGDGESAP
EEDSDGGEPQ KDDVLEDPNK ECDQNELAKN DDQGGSLEDR ESTHSSRATD KSEEPPLKPF
HNENFLESGS EYSEQDLFDN NKYANVKIQA FRQILHVHDK NVYTFFMNLI VHSKINLVRD
YKNKIFNAKV MATDILEYLL KNYFEADKFS VKGKVKKGGS QKQVHLSQVE LKNINEYICN
NSNSSSLKTL YHKILFLNNE NYESFKSRLL EGGVINLINL FHDEDINNFD KIFDVSFVNF
CDIVGISKDT CTYHFNCMDK NYKGKRYIYL KHIFRYLEVE RDMKDDLHKY NFISMQKKNL
IYIHINESFD NLKTFFKSVE KKNNLYISLN EFIYFFSENE KMEKYCYSQE DVTCLYYSIL
FYVYYTNKNK VLQTLEFWGE PSGGEENNPQ KTGPTQKNDY NKNELHRAPA SVAVNPLVDQ
TRENRSPPDD GYNYVNHNLS LYKEYFSLDD FNFAIELKDL YFYFEGFECP FSKIKRRILE
IYGSVKRGLI INHETCNSER DEDDTSSSQS DEEEAADLDV DLQLDSFQLF TRHKYRYKHS
DRVCFYERKV SSLAKVDREV EPDSLEDVGT IPPISKKIFM CLMYNIGIHV DHCLALWKSF
APFLEYDKLD YKVFCGFLNG KITVGSHETE EGIKEIKTKL INTKEEEEAD SICIHKNRLR
GTICPRLLNN LSEKDSTQPL TVDEIEVLTQ VLNHVTPFNF LDKNEIKNFI QKLKKKCFKE
GHDFVSLGGE RDIKIGKKEE KEISYGETTG NSYQNNTIVI LLNGILRHTT EPNSFINSIN
VIDRANVRSY TAHTNVAVIE INKELYTSDF VKLVEQKREV SEEFMSIIDD VPIIRNLPDA
LKKSLSMNVQ KCTYKKKKVI IRQHDDPTHF YILKQGEIHF YCNSVMSTPV RVISRCSFFG
EVALIFNTLR TCDAVVESDV AHCYCISREY FLSLLNKQIV KEFVEYFRTN YTHGIQHIIK
NYSSGNIAAE GATLQVDNNG ENRPNAGNML QKLPSDGDKM LIEVKRSSSR KYTNQLSTVG
SLNRDFSSVT LSEDNITLDV EYINKSNMTS FYSDLDKILL KFFNTEQKYF VEEMESHLMK
VKVLKKVLNK MKDKETFLKN LKWEKCPKGK HLILEGDLFD KFYFVKEGEI SVQQFNQYKN
VYEEISTVRQ NQYFGHQLIL NKTKSSFIAV ASVDTELYTL EASLYEKFLA PFIDTLNKKN
DINHTDELTK SINNQVMMKK DNDFVIKVIR ILKKVNVLQN LNNDQMYNGA KHFNFKFFRK
GTIIIRHNDT PDHFYIIKKG IVSVKVDDKE VEDVQHMNNL HNTDNNQKEE STHRGGRTKS
VYLYKYDYFG ELSIINNQLR TATCEAHTNC FLLAIDKDSF IEHFGIIFNE LLQEADVRYT
KNYSLPPWLK SMYGNGEFNE DMHSVSMKIP ELGSSLSSIS DDNNEMFSFE KEINAKLKKE
KRNKKKRNLK GRNANDEDTD DRPHAENENE VEHGSSINLS TNRSLSIVSN EDRISKIKEE
KKQEIQEIKL KELKVFERIK RKEEKKMKAL MKKKGVLLPE KNEKEELNPD QPSGNKRDEK
EEGGAPVEEA KMTTLNHESN RKENASQSKD NKQSSIQHKS SSILKKKINP PNSSDLKVDK
MVNKLMRLIC SEYNSIFHFY ECIDKFNTGY IKYNDFLNFI ASQNLEELFE GRDNMESLFK
YLCDGKGILT LTQFYISMYR DEDIDMYSLN LRLCEVYGSS LLAFKKIVPQ FNAQDDSLCS
FANFELVCDS VGLSKTNIKN IWDEINIMNE EQIPLEVVFS ILNGEVFVEQ AYVAYNEKKS
LLNRVVHFFQ ANEADFIKMS TEVMETNFKI NYEEPIIINK CQHKSCSNEC QELEKLLQLD
IHFKYLTLDQ RKFFATLMNR KIMKSGDVVT KQGDNDAPII FLYQGTANII SHNIFGIETV
IREIENEELY GCYEAIQGTP ADYEVKICSD NAVVWILDRS SYNDHLKDML EERKQNCLHI
LALLKNVPIL RYLPEETLQN ISYAMKVEHY QPNHTIIKEN THDDKFYIIC NGLATVEKNS
EINKNRLILS TLRKADFFGE IALIKNIRRT ANVILDTQTI LLSLVDVEFR RLLSPYFDQF
LNRAKANYKK LHLDIKLVPA EIASISSNPN IGNVVFGRGA RKKVTIQGFE EGDSPVEDPR
GKKKGEVSFV QSAEEAPLDE EPTEGSRNSH QGDSSKGGHD KHTGKAKDKG MSKTKKGKEH
GLQGEDAKGT EKKKGKIKEA HK
//