ID A0A0D9QS40_PLAFR Unreviewed; 549 AA.
AC A0A0D9QS40;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=ribose-phosphate diphosphokinase {ECO:0000256|ARBA:ARBA00013247};
DE EC=2.7.6.1 {ECO:0000256|ARBA:ARBA00013247};
GN ORFNames=AK88_00345 {ECO:0000313|EMBL:KJP89889.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP89889.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP89889.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC {ECO:0000256|ARBA:ARBA00006478}.
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DR EMBL; KQ001647; KJP89889.1; -; Genomic_DNA.
DR RefSeq; XP_012333419.1; XM_012477996.1.
DR AlphaFoldDB; A0A0D9QS40; -.
DR EnsemblProtists; KJP89889; KJP89889; AK88_00345.
DR GeneID; 24265659; -.
DR VEuPathDB; PlasmoDB:AK88_00345; -.
DR OMA; EFWIRMK; -.
DR OrthoDB; 276387at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 2.
DR InterPro; IPR029099; Pribosyltran_N.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR005946; Rib-P_diPkinase.
DR NCBIfam; TIGR01251; ribP_PPkin; 1.
DR PANTHER; PTHR10210:SF32; RIBOSE-PHOSPHATE DIPHOSPHOKINASE; 1.
DR PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR Pfam; PF14572; Pribosyl_synth; 1.
DR Pfam; PF13793; Pribosyltran_N; 1.
DR SMART; SM01400; Pribosyltran_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 2.
PE 3: Inferred from homology;
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727}.
FT DOMAIN 159..281
FT /note="Ribose-phosphate pyrophosphokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13793"
FT REGION 115..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 62708 MW; 9776FC78F1EF14EB CRC64;
MIYRIYNYSR KLYEHRDKFV KYFSAKNESV NIYHDKFQKS VYFMYENANH YNFNEYPVVL
NQERKRHNER RSHVKTKTIL FANILGLVMP SKNDENTENK DINIKKNEFS LINNKGRMST
NSKDTPNLEA DCMHPGKNNK KSKDDKYEYY QELSEYSNMQ IFSSNSHHEL ANEICSNLGI
GLGRAYVGKY SDGEIALQIM DEVRGRDIYI IHSTPSGGKD IHSRLMELFL FVSTLRRSSA
KKVTAVIPYL NYSRQTKHLD DFNYVHSLGA PEIAILLQAC GVDAIISVDL HSPRIEGFST
DEKLFQPPLM NINPQSLAVE YFKKKKLQNP VIVSIDNDGA ERTKEFWIRM KKYSLNAGFT
TIVSSSYNEM DSREGHPNDD GNEGKNTSSK KYLNIFSQDR RKNSNTTNPV KNVDNKNINQ
ITPNFKKEEF TIVGDIKGCD CILVDDILDT GEKSKKVAAL LKSAGASKIY LYATHPILSD
GCIENINESC IDEVVTTNTI HIPSNICCEK LHILSVAKLL AEGIKRVQNE PSQNALEDFS
DGEVIMKEK
//
