ID A0A0D9QUZ9_CHLSB Unreviewed; 720 AA.
AC A0A0D9QUZ9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Engulfment and cell motility 3 {ECO:0000313|Ensembl:ENSCSAP00000000188.1};
GN Name=ELMO3 {ECO:0000313|Ensembl:ENSCSAP00000000188.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000000188.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000000188.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000000188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; AQIB01129748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9QUZ9; -.
DR STRING; 60711.ENSCSAP00000000188; -.
DR Ensembl; ENSCSAT00000001852.1; ENSCSAP00000000188.1; ENSCSAG00000003824.1.
DR eggNOG; KOG2999; Eukaryota.
DR GeneTree; ENSGT00940000159455; -.
DR OMA; CPHIREK; -.
DR Proteomes; UP000029965; Chromosome 5.
DR Bgee; ENSCSAG00000003824; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF16; ENGULFMENT AND CELL MOTILITY PROTEIN 3; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 307..479
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 720 AA; 81428 MW; 1C0E56637900C77A CRC64;
MTPPRNVVKI AIQMRDAIPQ LIQLDQAKPL AAVLKEVCDA WSLTHSERYA LQFADGHRRY
ITENNRAEIK NGSILCLSTA PDLEAEQLLG GLQSDSREGR REALRHLVPL ASDMTFAREV
ISRNGLQRLG TIIEDGDDLG EVLALSLRAF LELMEHGVVS WETLSIPFVR KVVCYVNMNL
MDASVPPLAL GLLESVTLSS PALGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ
GASPVERKHM LDYLWQRNLR QFIYKNIIHS AAPMGDEMAH HLYVLQALTL GLLEPRMRTP
LDPYSQEQRE QLQVLRQAAF EVEGESSGTG LSADRCRSLC AQEFRKLGFS NSNPAQDLER
VPPGLLALDN MLYFSRNAPS AYSRFVLENS SREDKHECPF ARGSIQLTVL LCELLHVGEP
CSETAQDFSP MFFGQDQSFH ELFCVGIQLL NKTWKEMRAT QEDFDKVMQV VREQLARTLA
LKPTSLELFR TKVNALTYGE VLRLRQTERL HQEGTLAPPI LELREKLKPE LMVLIRQQRL
LRLCEGTLFR KISSRRRQDK LWFCCLSPNH KLLQYGDMEE GASPPTLESL PEQLPVADMK
ALLTGKDCPH VREKGSGKQN KDLYELAFSI SYDCGEEEAY LNFIAPSKRE FYLWTDGLSA
LLGSPMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPEQPP PVPPPPTNFN FCYDCSIAEP
//
