ID A0A0D9QX32_CHLSB Unreviewed; 980 AA.
AC A0A0D9QX32;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Eukaryotic translation initiation factor 4 gamma 2 {ECO:0000256|ARBA:ARBA00040449};
GN Name=EIF4G2 {ECO:0000313|Ensembl:ENSCSAP00000000921.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000000921.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000000921.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000000921.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Appears to play a role in the switch from cap-dependent to
CC IRES-mediated translation during mitosis, apoptosis and viral
CC infection. Cleaved by some caspases and viral proteases.
CC {ECO:0000256|ARBA:ARBA00037759}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01085255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9QX32; -.
DR STRING; 60711.ENSCSAP00000000921; -.
DR Ensembl; ENSCSAT00000002621.1; ENSCSAP00000000921.1; ENSCSAG00000004613.1.
DR eggNOG; KOG0401; Eukaryota.
DR GeneTree; ENSGT00940000154675; -.
DR OMA; CAPLDIN; -.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000004613; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016281; C:eukaryotic translation initiation factor 4F complex; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:Ensembl.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF82; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 616..739
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 793..977
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 110166 MW; 2217A1FDC84905EE CRC64;
MAGWQTPAGP RPWRTEARVC SDGEGARLGP RAPRREARGA SRRGGISFLP SPPLPTPSIN
IILLKILRCQ AAKVESAIAE GGASRFSASS GGGGSRGAPQ HYPKTAGNSE FLGKTPGQNA
QKWIPARSTR RDDNSAANNS ANEKERHDAI FRKVRGILNK LTPEKFDKLC LELLNVGVES
KLILKGVILL IVDKALEEPK YSSLYAQLCL RLAEDAPNFD GPAAEGQPGQ KQSTTFRRLL
ISKLQDEFEN RTRNVDVYDK RENPLLPEEE EQRAIAKIKM LGNIKFIGEL GKLDLIHESI
LHKCIKTLLE KKKRVQLKDM GEDLECLCQI MRTVGPRLDH ERAKSLMDQY FARMCSLMLS
KELPARIRFL LQDTVELREH HWVPRKAFLD NGPKTINQIR QDAVKDLGVF IPAPMAQGMR
SDFFLEGPFM PPRMKIDRDP LGGLADMFGQ MPGSGIGTGP GVIQDRFSPT MGRHRSNQLF
NGHGGHIMPP TQSQFGEMGG KFMKSQGLSQ LYHNQSQGLL SQLQGQSKDM PPRFSKKGQL
NADEISLRPA QSFLMNKNQV PKLQPQITMI PPSAQPPRTQ TPPLGQTPQL GLKTNPPLIQ
EKPAKTSKKP PPSKEELLKL TETVVTEYLN SGNANEAVNG VREMRAPKHF LPEMLSKVII
LSLDRSDEDK EKASSLISLL KQEGIATSDN FMQAFLNVLD QCPKLEVDIP LVKSYLAQFA
ARAIISELVS ISELAQPLES GTHFPLFLLC LQQLAKLQDR EWLTELFQQS KVNMQKMLPE
IDQNKDRMLE ILEGKGLSFL FPLLKLEKEL LKQIKLDPSP QTIYKWIKDN ISPKLHVDKG
FVNILMTSFL QYISSEVNPP SDETDSSSAP SKEQLEQEKQ LLLSFKPVMQ KFLHDHVDLQ
VSALYALQVH CYNSNFPKGM LLRFFVHFYD MEIIEEEAFL AWKEDITQEF PGKGKALFQV
NQWLTWLETA EEEESEEEAD
//
