ID A0A0D9QY41_CHLSB Unreviewed; 493 AA.
AC A0A0D9QY41;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Cholesteryl ester transfer protein {ECO:0000256|ARBA:ARBA00022354, ECO:0000256|PIRNR:PIRNR037185};
GN Name=CETP {ECO:0000313|Ensembl:ENSCSAP00000001280.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000001280.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000001280.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000001280.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the transfer of neutral lipids, including
CC cholesteryl ester and triglyceride, among lipoprotein particles. Allows
CC the net movement of cholesteryl ester from high density
CC lipoproteins/HDL to triglyceride-rich very low density
CC lipoproteins/VLDL, and the equimolar transport of triglyceride from
CC VLDL to HDL. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-
CC octadecenoyl)-glycerol(out); Xref=Rhea:RHEA:43352, ChEBI:CHEBI:53753;
CC Evidence={ECO:0000256|ARBA:ARBA00001417};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl
CC (9Z,12Z)-octadecadienoate(out); Xref=Rhea:RHEA:43356,
CC ChEBI:CHEBI:41509; Evidence={ECO:0000256|ARBA:ARBA00001140};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-
CC octadecenoate)(out); Xref=Rhea:RHEA:43348, ChEBI:CHEBI:46898;
CC Evidence={ECO:0000256|ARBA:ARBA00000222};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037185}.
CC Note=Secreted in plasma. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000256|ARBA:ARBA00007292, ECO:0000256|PIRNR:PIRNR037185}.
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DR EMBL; AQIB01137343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9QY41; -.
DR STRING; 60711.ENSCSAP00000001280; -.
DR Ensembl; ENSCSAT00000002987.1; ENSCSAP00000001280.1; ENSCSAG00000004959.1.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01100000263545; -.
DR OMA; MVLYMEK; -.
DR Proteomes; UP000029965; Chromosome 5.
DR Bgee; ENSCSAG00000004959; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-UniRule.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0005548; F:phospholipid transporter activity; IEA:Ensembl.
DR GO; GO:0017129; F:triglyceride binding; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:UniProtKB-UniRule.
DR GO; GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Ensembl.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:Ensembl.
DR GO; GO:0055091; P:phospholipid homeostasis; IEA:Ensembl.
DR GO; GO:0032376; P:positive regulation of cholesterol transport; IEA:Ensembl.
DR GO; GO:2001140; P:positive regulation of phospholipid transport; IEA:Ensembl.
DR GO; GO:0010874; P:regulation of cholesterol efflux; IEA:Ensembl.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:InterPro.
DR GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
DR GO; GO:0034197; P:triglyceride transport; IEA:UniProtKB-UniRule.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:UniProtKB-UniRule.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017130; Cholesteryl_ester_transfer.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017954; Lipid-bd_serum_glycop_CS.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47616; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR PANTHER; PTHR47616:SF1; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR PIRSF; PIRSF037185; Cholesteryl_ester_transf; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
DR PROSITE; PS00400; LBP_BPI_CETP; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037185-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037185};
KW Signal {ECO:0000256|PIRNR:PIRNR037185};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037185}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT CHAIN 18..493
FT /note="Cholesteryl ester transfer protein"
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT /id="PRO_5015219135"
FT DOMAIN 31..258
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
FT DOMAIN 272..476
FT /note="Lipid-binding serum glycoprotein C-terminal"
FT /evidence="ECO:0000259|SMART:SM00329"
FT DISULFID 160..201
FT /evidence="ECO:0000256|PIRSR:PIRSR037185-50"
SQ SEQUENCE 493 AA; 54705 MW; 360651412B879ED1 CRC64;
MLAATVLTLA LLGNVHACSK GTSHKAGIVC RITKPALLVL NQETAKVIQS AFQRANYPNI
TGEKAMMLLG QVKYGLHNIQ ISHLSIASSR VELVEAKSID VSIQNVSVVF KGTLKYGYTT
AWGLGIDQSV DFEIDSAIDL QINTQLTCDS GRVRTDAPDC YLSFHKLLLH LQGEREPGWI
KQLFTNFISF TLKLVLKGQI CKEINVISNI MADFVQTRAA SILSDGDIGV DISLTGDPII
TASYLESHHK GYFIYKNVSE DFPLPTFSPA LLGDSRMLYF WFSEQVFHSL AKVAFQDGRL
TLSLMGDEFK AVLETWGFNT NQEIFQEVVG GFPSQAQVTV HCLKMPKISC QNKGVVVNSS
VMVKFLFPRP DQQHSVAYTF EEDIMTTVQA SYSKKKLFLS LLDFQITPKT VSNLTESSSE
SVQSFLQSMI TTVGIPEVMS RLEAVFTALM NSKGLSLFDI INPEIITRDG FLLLQMDFGF
PEHLLVDFLQ SLS
//
