ID A0A0D9QYP9_CHLSB Unreviewed; 912 AA.
AC A0A0D9QYP9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO5 {ECO:0000313|Ensembl:ENSCSAP00000001488.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000001488.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000001488.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000001488.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR EMBL; AQIB01085088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01085089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9QYP9; -.
DR STRING; 60711.ENSCSAP00000001488; -.
DR Ensembl; ENSCSAT00000003210.1; ENSCSAP00000001488.1; ENSCSAG00000005168.1.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000155692; -.
DR OMA; LRNVQYW; -.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000005168; Expressed in Ammon's horn and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF23; ANOCTAMIN-5; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 301..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 382..400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 458..491
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 511..532
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 555..576
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 676..698
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 732..752
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 824..849
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 71..288
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 291..867
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 912 AA; 106908 MW; E3A9B60623D7C813 CRC64;
MGDPNLLEVL TEEGEHANKH IDYSFQMSES LSSRETSFLI NEETTPAKRF NLFLRRRLMF
QKNQQSKDSI FFRDGIRQID FVLSYADDIK KDAELKAERR KEFEKNLRKT GLELEIEDKR
DSEDGRTYFV KIHAPWEVLV TYAEVLGIKM PIKESDIPRP KQTPMSYVLG PVSLPPSVKY
PHPEYFTAQF SRHRQELFLI EDQATFFPSS SRNRIVYYIL SRCPFGIEDG KKRFGIERLL
NSNTYSSAYP LHDGQYWKPS EPPNPTNERY ILHQNWARFS YFYKEQPLDL IKNYYGEKIG
IYFVFLGFYT EMLSFAAVVG LACFIYGLLS MEDNTSSTEI CDPEIGGQMI MCPLCDQVCD
YWRLNSTCLA SKFSHLFDNE STVFFAIFMG IWVTLFLEFW KQRQARLEYE WDLVDFEEEQ
QQLQLRPEFE AMCKHRKLNP VTKEMEPYMP LYARIPWYFL SGATVTLWMS LVVTSMVAVI
VYRLSVFATL ASFMESDASL KQVKSFLTPQ ITTSLTGSCL NFIVILILNF FYEKISAWIT
KMEIPRTYQE YESSLTLKMF LFQFVNFYSS CFYVAFFKGK FVGYPGKYTY LFDEWRSEEC
DPGGCLIELT TQLTIIMTGK QIFGNIKEAI YPLALNWWRR RKARTNSEKL YSRWEQDHDL
ESFGPLGLFY EYLETVIQFG FVTLFVASFP LAPLLALINN IVEIRVDAWK LTTQYRRTVA
SKAHSIGVWQ DILYGMAVLS VATNAFIVAF TSDIIPRLVY YYAYSTNATQ PMKGYVNNSL
SVFLIADFPN HTAPSEKRDF ITCRYRDYRY PPDDENKYFH NMQFWHVLAA KMTFIIVMEH
VVFLVKFLLA WMIPDVPKDV VERIKREKLM TIKILHDFEL NKLKENLGIN SNEFAKHVMI
EENKAQLAKS TI
//
