ID   A0A0D9QYQ8_CHLSB        Unreviewed;       845 AA.
AC   A0A0D9QYQ8;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSCSAP00000001497.1};
GN   Name=SORCS1 {ECO:0000313|Ensembl:ENSCSAP00000001497.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000001497.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000001497.1, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000001497.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   EMBL; AQIB01042488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01042489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01042490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A0D9QYQ8; -.
DR   STRING; 60711.ENSCSAP00000001497; -.
DR   Ensembl; ENSCSAT00000003209.1; ENSCSAP00000001497.1; ENSCSAG00000005204.1.
DR   eggNOG; KOG3511; Eukaryota.
DR   GeneTree; ENSGT01030000234563; -.
DR   OMA; AYSHEQK; -.
DR   Proteomes; UP000029965; Chromosome 9.
DR   Bgee; ENSCSAG00000005204; Expressed in caudate nucleus and 4 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        760..778
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          494..551
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          801..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..817
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   845 AA;  94955 MW;  A8E4554514B582AD CRC64;
     SHYLTCRMQN CTEANRNQPF PGYIDPDSLI VQDHYVFVQL TSGGRPHYYV SYRRNAFAQM
     KLPKYALPKD MHVISTDENQ VFAAVQEWNQ NDTYNLYISD TRGVYFTLAL ENVQSSRGPE
     GNIMIDLYEV AGIKGMFLAN KKIDNQVKTF ITYNKGRDWR LLQAPDTDLR GDPVHCLLPY
     CSLHLHLKVS ENPYTSGIIA SKDTAPSIIV ASGNIGSELS DTDISMFVSS DAGNTWRQIF
     EEEHSVLYLD QGGVLVAMKH TSLPIRHLWL SFDEGRSWSK YSFTSIPLFV DGVLGEPGEE
     TLIMTVFGHF SHRSEWQLVK VDYKSIFDRR CAEEDYRPWQ LHSQGEACIM GAKRIYKKRK
     SERKCMQGKY AGAMESEPCV CTEADFDCDY GYERHSNGQC LPAFWFNPSS LSKDCSLGQS
     YLNSTGYRKV VSNNCTDGVR EQYTAKPQKC PGKAPRGLRI VTADGKLTAE QGHNVTLMVQ
     LEEGDVQRTL IQVDFGDGIA VSYVNLSSME DGIKHVYQNV GIFRVTVQVD NSLGSDSAVL
     YLHVTCPLEQ VHLSLPFVTT KNKEVNATAV LWPSQVGTLT YVWWYGNNTE PLITLEGSIS
     FRFTSEGMNT ITVQVSAGNA ILQDTKTIAV YEEFRSLRLS FSPNLDDYNP DIPEWRRDIG
     RVIKKSLVEA TGVPGQHILV AVLPGLPTTA ELFVLPYQDP AGENKRSADD LEQISELLIH
     KLNQNSVHFE LKPGVRVLVH AAHLTAAPLV DLTPTHSGSA MLMLLSVVFV GLAVFVIYKF
     KRKIPGINVY AQMQNEKEQE MISPVSHSES RPNVPQTELR RPGQLIDEKV ESQLIGRYRS
     TLQSL
//