ID A0A0D9R038_CHLSB Unreviewed; 348 AA.
AC A0A0D9R038;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Erlin {ECO:0000256|RuleBase:RU369041};
DE Short=SPFH domain-containing protein {ECO:0000256|RuleBase:RU369041};
DE AltName: Full=Endoplasmic reticulum lipid raft-associated protein {ECO:0000256|RuleBase:RU369041};
DE AltName: Full=Stomatin-prohibitin-flotillin-HflC/K domain-containing protein {ECO:0000256|RuleBase:RU369041};
GN Name=ERLIN1 {ECO:0000313|Ensembl:ENSCSAP00000001977.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000001977.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000001977.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000001977.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the endoplasmic reticulum-associated degradation
CC (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in
CC regulation of cellular cholesterol homeostasis by regulation the SREBP
CC signaling pathway. {ECO:0000256|RuleBase:RU369041}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369041}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU369041}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family.
CC {ECO:0000256|ARBA:ARBA00008164, ECO:0000256|RuleBase:RU369041}.
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DR EMBL; AQIB01042664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007962020.1; XM_007963829.1.
DR AlphaFoldDB; A0A0D9R038; -.
DR SMR; A0A0D9R038; -.
DR STRING; 60711.ENSCSAP00000001977; -.
DR Ensembl; ENSCSAT00000003700.1; ENSCSAP00000001977.1; ENSCSAG00000005667.1.
DR GeneID; 103216381; -.
DR CTD; 10613; -.
DR eggNOG; KOG2962; Eukaryota.
DR GeneTree; ENSGT00390000014666; -.
DR OMA; CAFQQAN; -.
DR OrthoDB; 3129813at2759; -.
DR BioGRID-ORCS; 103216381; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 9.
DR Bgee; ENSCSAG00000005667; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045541; P:negative regulation of cholesterol biosynthetic process; IEA:Ensembl.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:Ensembl.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:Ensembl.
DR CDD; cd03406; SPFH_like_u3; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR033294; Erlin1/2.
DR PANTHER; PTHR15351; ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG; 1.
DR PANTHER; PTHR15351:SF2; ERLIN-1; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|RuleBase:RU369041};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU369041};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU369041};
KW Lipid metabolism {ECO:0000256|RuleBase:RU369041};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968,
KW ECO:0000256|RuleBase:RU369041};
KW Steroid metabolism {ECO:0000256|RuleBase:RU369041};
KW Sterol metabolism {ECO:0000256|RuleBase:RU369041};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 23..189
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT REGION 325..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 39185 MW; 859C8C9AF777D7AE CRC64;
MNMTQARVLV AAVVGLVVVL LYASIHKIEE GHLAVYYRGG ALLTSPSGPG YHIMLPFITT
FRSVQTTLQT DEVKNVPCGT SGGVMIYIDR IEVVNMLAPY AVFDIVKNYT ADYDKTLIFN
KIHHELNQFC SAHTLQEVYI ELFDQIDENL KQALQKDLNL MAPGLTIQAV RVTKPKIPEA
IRRNFELMEA EKTKLLIAAQ KQKVVEKEAE TERKKAVIEA EKIAQVAKIR FQQKVMEKET
EKRISEIEDA AFLAREKAKA DAEYYAAHKY ATSNKHKLTP EYLELKKYQA IASNSKIYFG
SNIPNMFVDS SCALKYSDIR TGRESSLPSK EALEPSGENL IQNKESTG
//
