ID   A0A0D9R0B1_CHLSB        Unreviewed;       496 AA.
AC   A0A0D9R0B1;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=NEU4 {ECO:0000313|Ensembl:ENSCSAP00000002050.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002050.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000002050.1, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000002050.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; AQIB01000032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007965211.1; XM_007967020.1.
DR   AlphaFoldDB; A0A0D9R0B1; -.
DR   STRING; 60711.ENSCSAP00000002050; -.
DR   Ensembl; ENSCSAT00000003776.1; ENSCSAP00000002050.1; ENSCSAG00000005741.1.
DR   GeneID; 103218251; -.
DR   CTD; 129807; -.
DR   eggNOG; ENOG502QSFT; Eukaryota.
DR   GeneTree; ENSGT00950000182944; -.
DR   OMA; GRTWHCG; -.
DR   OrthoDB; 5482010at2759; -.
DR   BioGRID-ORCS; 103218251; 0 hits in 9 CRISPR screens.
DR   Proteomes; UP000029965; Chromosome 10.
DR   Bgee; ENSCSAG00000005741; Expressed in caudate nucleus and 2 other cell types or tissues.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0019866; C:organelle inner membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006689; P:ganglioside catabolic process; IEA:Ensembl.
DR   GO; GO:0006516; P:glycoprotein catabolic process; IEA:Ensembl.
DR   GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IEA:Ensembl.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 2.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF22; SIALIDASE-4; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT   DOMAIN          57..278
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          296..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          476..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  52856 MW;  CDE45751298EC435 CRC64;
     MMSSAAFPRW PSMGAPHTPS RTVLFERERT GLTYRVPSLL PVPPGPTLLA FVEQRLSPDD
     SHAHRLVLRR GTRAGGSVRW GALQVLGTAA LAEHRSMNPC PVHDTGTGTV FLFFIAVLGH
     TPEAVQIATG RNAARLCYVA SRDAGLSWGS ARDLTEEAIG GAVQDWATFA VGPGHGVQLP
     SGRLLVPAYT YRVDRRECFG KICRTSPHSF AFYSDDHGRT WRCGGLVPNL RSGECQLAAV
     DGGQAGSFLY CNARSTLGSR VQALSTDEGT SFLPAERVAS LPETAWGCQG SIVGFPAPAP
     SRPRDDGWSV GPGSPLHPPR LGPGVHEPPE EAAGDPHGGQ VPGGPCSHLQ PQGDGPRQPG
     PRPGVSGDVG SWTLALPMPF AAPPQSPTWL LYSHPVGRRA RLHMGIRLSR APLDPHSWTE
     PWVIYEGPSG YSDLASVGPA PEGGLVFACL YESGARTSYD EISFCTFSLR EVLENVPTSP
     EPPNLGDKPR GCCWPS
//