ID A0A0D9R0J7_CHLSB Unreviewed; 586 AA.
AC A0A0D9R0J7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Ran GTPase activating protein 1 {ECO:0000313|Ensembl:ENSCSAP00000002136.1};
GN Name=RANGAP1 {ECO:0000313|Ensembl:ENSCSAP00000002136.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002136.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002136.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002136.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01148965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007974094.1; XM_007975903.1.
DR AlphaFoldDB; A0A0D9R0J7; -.
DR STRING; 60711.ENSCSAP00000002136; -.
DR Ensembl; ENSCSAT00000003864.1; ENSCSAP00000002136.1; ENSCSAG00000005830.1.
DR GeneID; 103223376; -.
DR CTD; 5905; -.
DR eggNOG; KOG1909; Eukaryota.
DR GeneTree; ENSGT00440000039203; -.
DR OMA; NGSMEAW; -.
DR OrthoDB; 3025421at2759; -.
DR BioGRID-ORCS; 103223376; 3 hits in 16 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 19.
DR Bgee; ENSCSAG00000005830; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0106068; C:SUMO ligase complex; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0046826; P:negative regulation of protein export from nucleus; IEA:Ensembl.
DR GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 1.25.40.200; Ran-GTPase activating protein 1, C-terminal domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR009109; Ran_GTPase_activating_1_C.
DR InterPro; IPR027038; RanGap.
DR InterPro; IPR036720; RanGAP1_C_sf.
DR PANTHER; PTHR24113; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR24113:SF5; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF07834; RanGAP1_C; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SUPFAM; SSF69099; Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 408..583
FT /note="Ran-GTPase activating protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07834"
FT REGION 357..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..398
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 63321 MW; EE74BCD59618BFF9 CRC64;
MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT
VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS
DNAFGPDGVQ GFEALLKSSA CFTLHELKLN NCGMGIGGGK ILAAALTECH RKSSAQGKPL
ALKVFVAGRN RLENDGATAL AEAFRVIGTL EEVHMPQNGI NHPGVTALAQ AFAVNPLLRV
INLNDNTFTE KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL
SFCEIKRDAA LAVAEAMADK TELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD
EDEEEEEGEE EEEAEEEEEE EEEEEEEEEE EEEEEEPQQG GQGEKSATPS QKILDPNTGE
PAPMLSSPPP ADVSTFLAFP SPEKLLRLGP KSSMLIAQQT DTSDPEKVVF AFLKVSSVFK
DEATVRTAVQ DAVDALMKKA FSSSSFNSSA FLTRLLAHMG LLKSEDKVKA IANLYGPLMA
LNHMVQQDYF PKALAPLLLA FITKPNSALE SCSFARHSLL QTLYKV
//
