ID A0A0D9R0W7_CHLSB Unreviewed; 340 AA.
AC A0A0D9R0W7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=NOP2/Sun RNA methyltransferase 3 {ECO:0000313|Ensembl:ENSCSAP00000002256.1};
GN Name=NSUN3 {ECO:0000313|Ensembl:ENSCSAP00000002256.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002256.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002256.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002256.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; AQIB01103832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01103841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007984331.1; XM_007986140.1.
DR AlphaFoldDB; A0A0D9R0W7; -.
DR SMR; A0A0D9R0W7; -.
DR STRING; 60711.ENSCSAP00000002256; -.
DR Ensembl; ENSCSAT00000003987.1; ENSCSAP00000002256.1; ENSCSAG00000005953.1.
DR GeneID; 103228513; -.
DR KEGG; csab:103228513; -.
DR CTD; 63899; -.
DR eggNOG; KOG2198; Eukaryota.
DR GeneTree; ENSGT00940000153665; -.
DR OMA; FNRFNYP; -.
DR OrthoDB; 317522at2759; -.
DR BioGRID-ORCS; 103228513; 1 hit in 16 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 22.
DR Bgee; ENSCSAG00000005953; Expressed in Ammon's horn and 7 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016428; F:tRNA (cytidine-5-)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0070129; P:regulation of mitochondrial translation; IEA:Ensembl.
DR GO; GO:0002127; P:tRNA wobble base cytosine methylation; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 6.20.240.40; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22808:SF8; TRNA (CYTOSINE(34)-C(5))-METHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 44..334
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 265
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 139..145
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 162
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 193
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 211
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 340 AA; 38325 MW; 0A1FB1E8F6856D1A CRC64;
MLTRLKAKSE GKLAKQICKV VLDHFEKQYS KELGDAWNTV RKILTSPSCW QYAVLLNRFN
YPFELEKDLH LKGYHTLFQG SLPNYPKSMK CYLSRTPGRI PSERHQIGNL KKYYLLNAAS
LLPVLALELR DGEKVLDLCA APGGKSIALL QCACPGYLHC NEYDSLRLKW LRQTLESFIP
QPLINVIEVS ELDGRKMGDA QPEMFDKVLV DAPCSNDRSW LFSSDSQKAS CRISQRRNLP
LLQIALLRSA IKALRPGGIL VYSTCTLSKA ENQDVISEIL NSHSNIMPMD IKGIARTCSH
DFTFSPTGQE CGLLVIPDKG KAWGPMYVAK LKKSWSTGKW
//
