ID A0A0D9R1E6_CHLSB Unreviewed; 598 AA.
AC A0A0D9R1E6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Melanophilin {ECO:0000313|Ensembl:ENSCSAP00000002435.1};
GN Name=MLPH {ECO:0000313|Ensembl:ENSCSAP00000002435.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002435.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002435.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01000853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01000862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007964963.1; XM_007966772.1.
DR AlphaFoldDB; A0A0D9R1E6; -.
DR Ensembl; ENSCSAT00000004176.1; ENSCSAP00000002435.1; ENSCSAG00000006137.1.
DR KEGG; csab:103218153; -.
DR eggNOG; ENOG502RJPZ; Eukaryota.
DR GeneTree; ENSGT00950000183138; -.
DR OMA; EAQGWLC; -.
DR OrthoDB; 2967336at2759; -.
DR BioGRID-ORCS; 103218153; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 10.
DR Bgee; ENSCSAG00000006137; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0017022; F:myosin binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd15752; FYVE_SlaC2-a; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR037442; Melanophilin_FYVE-rel_dom.
DR InterPro; IPR006788; Myrip/Melanophilin.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14555:SF1; MELANOPHILIN; 1.
DR PANTHER; PTHR14555; MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED; 1.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF04698; Rab_eff_C; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50916; RABBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 4..124
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT REGION 145..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 65745 MW; 0F8A92013F53D182 CRC64;
MGKKLDLSKL TDEEAQHILE VVQRDFDLRR KEEERLEGLK GKIKKESSKR ELLSDTAHLN
ETHCTHCLQP YRLLVNSKRQ CLKCGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW
YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PESISEERIG DSEQTDEEGE LDSEAQAQPF
GNKKKRLLSI QDFDFERDSD DSAQPQGHSL HLSSVLEARD SLQSLADESC LEKAAPQKAE
GLDGADTGAS GCQSHTEEEP MSISPSGHSA LAELCPPGGS HSMALGATAA LRSNVIRNEQ
LPLQYLADVD TSDEESIRAH VMASHHSKRR GRASSESQIF ELNKRISAVE RLLTYLENTV
LPPLAKGLGA GVRTEADVEE ETLRKKLEEL TSNVSDQGTS SEEEEAKDEK AEPDRGKSVG
AVPQADPEVS VAAHQTNRQE KSSQGPGDPV QHNRTTDEEL SELEDRVAVT ASEVQQAESE
VSDIESRIAA LRAAGLTVKP SGKPRRKSNL PIFVPRVAGK LGKRPEDPNA DPSSEAKAMA
APYLLRRKFS NSLKNQGKDD DSFDRKSVYR GSLTQRNPNG RKGMASHTFA KPVVAHQP
//
