ID A0A0D9R214_CHLSB Unreviewed; 162 AA.
AC A0A0D9R214;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Sperm acrosome membrane-associated protein 3 {ECO:0000256|ARBA:ARBA00016370};
GN Name=SPACA3 {ECO:0000313|Ensembl:ENSCSAP00000002653.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002653.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002653.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002653.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sperm surface membrane protein that may be involved in sperm-
CC egg plasma membrane adhesion and fusion during fertilization. It could
CC be a potential receptor for the egg oligosaccharide residue N-
CC acetylglucosamine, which is present in the extracellular matrix over
CC the egg plasma membrane. The processed form has no detectable
CC bacteriolytic activity in vitro. {ECO:0000256|ARBA:ARBA00024656}.
CC -!- SUBUNIT: Interacts with ASTL. {ECO:0000256|ARBA:ARBA00011780}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC membrane {ECO:0000256|ARBA:ARBA00004312}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004312}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000256|RuleBase:RU004440}.
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DR EMBL; AQIB01146921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9R214; -.
DR STRING; 60711.ENSCSAP00000002653; -.
DR Ensembl; ENSCSAT00000004400.1; ENSCSAP00000002653.1; ENSCSAG00000006362.1.
DR eggNOG; ENOG502S1F5; Eukaryota.
DR GeneTree; ENSGT00940000161810; -.
DR OMA; WVDGCEF; -.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000006362; Expressed in blood.
DR GO; GO:0043159; C:acrosomal matrix; IEA:Ensembl.
DR GO; GO:0002080; C:acrosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003796; F:lysozyme activity; IEA:InterPro.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:Ensembl.
DR GO; GO:0035036; P:sperm-egg recognition; IEA:Ensembl.
DR CDD; cd16897; LYZ_C; 1.
DR Gene3D; 1.10.530.10; -; 1.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PANTHER; PTHR11407; LYSOZYME C; 1.
DR PANTHER; PTHR11407:SF25; SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..162
FT /note="Sperm acrosome membrane-associated protein 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002344647"
FT DOMAIN 109..127
FT /note="Glycosyl hydrolases family 22 (GH22)"
FT /evidence="ECO:0000259|PROSITE:PS00128"
SQ SEQUENCE 162 AA; 18268 MW; D9A0E8D74174CEA6 CRC64;
EARSRALGRR WCPATIMLLA LVSLLSCLLP SSEAKVYSRC ELARVLQDFG LDGYRGYSLA
DWVCLAYFTS GFNTAAVDHE ADGSTNNGIF QISSRRWCRN LTPNAPNMCR MYCSDLLNPN
LKDTVICAMK ITQEPQGLGY WEAWRHHCQG KDLTDWVDGC DF
//
