ID A0A0D9R281_CHLSB Unreviewed; 434 AA.
AC A0A0D9R281;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Protein tyrosine phosphatase receptor type N2 {ECO:0008006|Google:ProtNLM};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002720.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002720.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01133737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9R281; -.
DR STRING; 60711.ENSCSAP00000002720; -.
DR Ensembl; ENSCSAT00000004464.1; ENSCSAP00000002720.1; ENSCSAG00000006423.1.
DR eggNOG; KOG0793; Eukaryota.
DR GeneTree; ENSGT00940000154095; -.
DR OMA; WHDQKVP; -.
DR Proteomes; UP000029965; Chromosome 21.
DR Bgee; ENSCSAG00000006423; Expressed in caudate nucleus and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14610; R-PTP-N2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 164..424
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 343..415
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 94..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 48982 MW; A393ED33B95D9553 CRC64;
MLCQELTYPS LLVLQKSKLK FLPRQAEQED STKFIALTLV SLACILGVLL ASGLIYCLRH
SSQHRLKEKL SGLGRDPGTD ATAAYQELCR QRMATRPPDR PEGPHTSRIS SVSSQFSDGP
MPSPSARSSA SSWSEEPVQS NMDISTGHMI LSYMEDHLKN KNRLEKEWEA LCAYQAEPNS
SLVAQKEENV PKNRSLAVLT YDHSRVLLKA ENSHSHSDYI NASPIMDHDP RNPAYIATQG
PLPATVADFW QMVWESGCVV IVMLTPLTEN GVRQCYHYWP DEGSNLYHIY EVNLVSEHIW
CEDFLVRSFY LKNLQTNETR TVTQFHFLSW YDRGVPSSSR SLLDFRRKVN KCYRGRSCPI
IVHCSDGAGR SGTYVLIDMV LNKMAKGAKE IDIAATLEHL RDQRPGMVQT KEQFEFALTA
VAEEVNAILK ALPQ
//
