ID A0A0D9R430_CHLSB Unreviewed; 379 AA.
AC A0A0D9R430;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Nuclear receptor subfamily 1 group I member 2 {ECO:0000313|Ensembl:ENSCSAP00000003369.1};
GN Name=NR1I2 {ECO:0000313|Ensembl:ENSCSAP00000003369.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000003369.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000003369.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000003369.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR EMBL; AQIB01110614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01110615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01110616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01110617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01110618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007983876.1; XM_007985685.1.
DR AlphaFoldDB; A0A0D9R430; -.
DR STRING; 60711.ENSCSAP00000003369; -.
DR Ensembl; ENSCSAT00000005139.1; ENSCSAP00000003369.1; ENSCSAG00000007092.1.
DR GeneID; 103228220; -.
DR KEGG; csab:103228220; -.
DR CTD; 8856; -.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000161118; -.
DR OMA; GTCEITQ; -.
DR OrthoDB; 5359733at2759; -.
DR BioGRID-ORCS; 103228220; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 22.
DR Bgee; ENSCSAG00000007092; Expressed in liver.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0042178; P:xenobiotic catabolic process; IEA:Ensembl.
DR GO; GO:0042908; P:xenobiotic transport; IEA:Ensembl.
DR CDD; cd06934; NR_LBD_PXR_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF39; NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..59
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 91..378
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 379 AA; 43928 MW; 12A1DAAEBF275D66 CRC64;
MTCEGCKGFF RRAMKRNARL RCPFRKGACE ITRKTRRQCQ ACRLRKCLES GMKKEMIMSD
AAVEERRALI KRKKRERIGT QPPGVQGLTE EQRMMIRELM DAQMKTFDTT FSHFKNFRLP
GVLSSGCEMP EFLQAPSREE AAKWSQVRKD LWSVKVSVQL RGEDGSVWNY KPPADNGGKE
IFSLLPHMAD MSTYMFKGII NFAKVISYFR DLPIEDQISL LKGATFELCQ LRFNTVFNAE
TGTWECGRLS YCLEDPAGGF QQLLLEPMLK FHYMLKKLQL HEEEYVLMQA ISLFSPDRPG
VVQHRVVDQL QEQYAITLKS YIECNRPQPA HRFLFLKIMA MLTELRSINA QHTQRLLRIQ
DIHPFATPLM QELFGITGS
//
