ID A0A0D9R6F7_CHLSB Unreviewed; 3274 AA.
AC A0A0D9R6F7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=SMG1 {ECO:0000313|Ensembl:ENSCSAP00000004196.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004196.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004196.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004196.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; AQIB01118390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000004196; -.
DR Ensembl; ENSCSAT00000005986.1; ENSCSAP00000004196.1; ENSCSAG00000007938.1.
DR eggNOG; KOG0891; Eukaryota.
DR GeneTree; ENSGT00940000154776; -.
DR OMA; AFECHFT; -.
DR Proteomes; UP000029965; Chromosome 5.
DR Bgee; ENSCSAG00000007938; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0033391; C:chromatoid body; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0032204; P:regulation of telomere maintenance; IEA:Ensembl.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR035175; SMG1_N.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR Pfam; PF17229; SMG1_N; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1257..1840
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2098..2437
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1872..1894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1948..1975
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3274 AA; 367656 MW; 6544CF4306468E2C CRC64;
MRFLRTDSAS ADPDNLKYSS SRDRGSSSSY GLQPSNSAVV SRQRHDDTRV HADIQNDEKG
GYSVNGGSGE NTYGRKSLGQ ELRVNNVTSP EFTSVQHGSR ALATKDMRKS QERSMSYSDE
SRLSNLLRRI TREDDRDRRL ATVKQLKEFI QQPENKLVLV KQLDNILAAV HDVLNESSKL
LQELRQEGAC CLGLLCASLS YEAEKIFKWI FSKFSSSAKD EVKLLYLCAT YKALETVGEK
KAFSSVMQLV MTSLQSILEN VDTPELLCKC VKCILLVARC YPHIFSTNFR DTVDILVGWH
IDHTQKPSLT QQVSGWLQSL EPFWVADLAF STTLLGQFLE DMEAYAEDLS HVASGESVDE
DVPPPSVSLP KLAALLRVFS TVVRSIGERF SPIRGPPITE AYVTDVLYRV MRCVTAANQV
FFSEAVLTAA NECVGVLLGS LDPSMTIHCD MVITYGLDQL ENCQTCGTDY IISVLNLLTL
IVEQINTKLP SSFVEKLFIP SSKLLFLRYH KEKEVVAVAH AVYQAVLSLK NIPVLETAYK
LILGEMTCAL NNLLHSLQLP EACSEIKHEA FKNHVFNVDN AKFVVIFDLS ALTTIGNAKN
SLIGMWALSP TVFALLSKNL MIVHSDLAVH FPAIQYAVLY TLYSHCTRHD HFISSSLSSS
SPSLFDGAVI STVTTATKKH FSIILNLLGI LLKKDNLNQD TRKLLMTWAL EVAVLMKKSE
TYAPLFSLPS FHKFCKGLLA NTLVEDVNIC LQACSSLHAL SSSLPDDLLQ RCVDVCRVQL
VHSGTRIRQA FGKLLKSIPL DVVLSNNNHT EIQEISLALR SHMSKAPSNT FHPQDFSDVI
SFILYGNSHR TGKDNWLERL FYSCQRLDKR DQSTIPRNLL KTDAVLWQWA IWEAAQFTVL
SKLRTPLGRA QDTFQTIEGI IRSLAAHTLN PDQDVSQWTT ADNDEGHGNN QLRLVLLLQY
LENLEKLMYN AYEGCANALT SPPKVIRTFF YTNRQTCQDW LTRIRLSIMR VGLLAGQPAV
TVRHGFDLLT EMKTTNLSQG NELEVTIMMV VEALCELHCP EAIQGIAVWS SSIVGKNLLW
INSVAQQAEG RFEKASVEYQ EHLCAMTGVD CCISSFDKSV LTLANAGRNS ASPKHSLNGE
SRKTVLSKPT DSSPEVINYL GNKACECYIS IADWAAVQEW QNAIHDLKKS TSSTSLNLKA
DFNYIKSLSS FESGKFVECT EQLELLPGEN INLLAGGSKE KIDMKKLLPN MLSPDPRELQ
KSIEVQLLRS SVCLATALNP VEQDQKWQSI TENVVKYLKQ TSRISIGPLR LSTLTVSQSL
PVLSTLQLYC SSALENTVSS RLSTEDCLIP LFSEALRSCK QHDVRPWMQA LRYTMYQNRL
LEKIKEQTVP IRSHLMELGL TAAKFARKRG NVSLATRLLA QCSEVQLGKT TTAQDLVQHF
KKLSTQGQVD EKWGPELDIE KTKLLYTAGQ STHAMEMLSS CAISFCKSAK AEYAVAKSIL
TLAKWIQAEW KEISGQLKQV YRAQHQQNFT GLSTLSKNIL TLIELPSVNT MEEEYPRIES
ESTVHIGVGE PDFILGQLYH LSSVQAPEVA KSWAALASWA YRWGRKVVDN ASQGEGVRLL
PREKSEVQNL LPDTITEEEK ERIYGILGQA VCRPAGIQDE DITLQITESE DNEEDDMVDV
IWRQLISSCP WLSELDESAT EGVIKVWRKV VDRIFSLYKL SCSAYFTFLK LNAGQIPLDE
DDPRLHLSHR AEQSTDDVIV MATLRLLRLL VKHAGELRQY LEHGLETTPT APWRGIIPQL
FSRLNHPEVY VRQSICNLLC RVAQDSPHLI LYPAIVGTIS LSSESQASGN KFSTAIPTLL
GNIQGEELLV SECEGGSPPA SQDSNKDEPK SGFNEDQAMM QDCYSKIVDK LSSANPTMVL
QVQMLVAELR RVTVLWDELW LGVLLQQHMY VLRRIQQLED EVKRVQNNNT LRKEEKIAIM
REKHTALMKP IVFALEHVRS ITAAPAETPH EKWFQDNYGD AIENALEKLK TPSNPAKPGS
SWIPFKEIML SLQQRAQKRA SYILRLEEIS PWLAAMTNTE IALPGEVSAR DTVTIHSVGG
TITILPTKTK PKKLLFLGSD GKSYPYLFKG LEDLHLDERI MQFLSIVNTM FATINRQETP
RFHARHYSVT PLGTRSGLIQ WVDGATPLFG LYKRWQQREA ALQAQKAQDS YQTPQNPGIV
PRPSELYYSK IGPALKTVGL SLDVSRRDWP LHVMKAVLEE LMEATPPNLL AKELWSSCTT
PDEWWRVTQS YARSTAVMSM VGYIIGLGDR HLDNVLIDMT TGEVVHIDYN VCFEKGKSLR
VPEKVPFRMT QNIETALGVT GVEGVFRLSC EQVLHIMRRG RETLLTLLEA FVYDPLVDWT
AGGEAGFAGA VYGGGGQQAE SKQSKREMER EITRSLFSSR VAEIKVNWFK NRDEMLIVLP
KLDSSLDEYL SLQEQLTDVE KLQGKLLEEI EFLEGAEGVD HPSHTLQHRY SEHTQLQTQQ
RAVQEAIQVK LNEFEQWITH YQAAFNNLEA TQLASLLQEI STQMDLGPPS YVPATAFLQN
AGQAHLISQC EQLEGEVGAL LQQRRSVLRG CLEQLHHYAT VALQYPKAIF QKHRIEQWKT
WMEELICNTT VERCQELYRK YEMQYAPQPP PTVCQFITAT EMTLQRYAAD INSRLIRQVE
RLKQEAVTVP VCEDQLKEIE RCIKVFLHEN GEEGSLSLAS VIISALCTLT RRNLMMEGAA
SSAGEQLVDL TSRDGAWFLE ELCSMSGNVT CLVQLLKQCH LVPQDLDIPN PMEASETVHL
ANGVYTSLQE LNSNFRQIIF PEALRCLMKG EYTLESMLHE LDGLIEQTTD GVPLQTLVES
LQAYLRNAAM GLEEETHAHY IDVARLLHAQ YGELIQPRNG SVEETPKMSA GQMLLVAFDG
MFAQVETAFG LLVEKLNKME IPIAWRKIDI IREARSTQVN FFDDDNHRQV LEEIFFLKRL
QTIKEFFRLC GTFSKTLSGS SSLEDQNTVN GPVQIVNVKT LFRNSCFSED QMAKPIKAFT
ADFVRQLLIG LPNQALGLTL CSFISALGVD IIAQVEAKDF GAESKVSVDD LCKKAVEHNI
QIGKFSQLVM NRATVLASSY DTAWKKHDLV RRLETSISSC KTSLQRVQLH IAMFQWQHED
LLINRPQAMS VTPPPRSAIL TSMKKKLHTL SQIETSIATV QEKLAALEAS IEQRLKWAGG
ANPALAPVLQ DFEATIAERR NLVLKESQRA SQVL
//
