ID   A0A0D9R6J6_CHLSB        Unreviewed;      1042 AA.
AC   A0A0D9R6J6;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Signal-induced proliferation-associated 1 {ECO:0000313|Ensembl:ENSCSAP00000004235.1};
GN   Name=SIPA1 {ECO:0000313|Ensembl:ENSCSAP00000004235.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004235.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000004235.1, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000004235.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AQIB01078583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01078584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007981983.1; XM_007983792.1.
DR   RefSeq; XP_007982065.1; XM_007983874.1.
DR   RefSeq; XP_007982144.1; XM_007983953.1.
DR   AlphaFoldDB; A0A0D9R6J6; -.
DR   STRING; 60711.ENSCSAP00000004235; -.
DR   Ensembl; ENSCSAT00000006021.1; ENSCSAP00000004235.1; ENSCSAG00000007975.1.
DR   GeneID; 103227440; -.
DR   KEGG; csab:103227440; -.
DR   CTD; 6494; -.
DR   eggNOG; KOG3686; Eukaryota.
DR   GeneTree; ENSGT00940000160644; -.
DR   OMA; PYDNIGG; -.
DR   OrthoDB; 25782at2759; -.
DR   BioGRID-ORCS; 103227440; 1 hit in 9 CRISPR screens.
DR   Proteomes; UP000029965; Chromosome 1.
DR   Bgee; ENSCSAG00000007975; Expressed in blood and 6 other cell types or tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF14; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT   DOMAIN          321..539
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          687..763
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          829..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          946..980
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..886
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        961..980
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1042 AA;  111975 MW;  D999C0325149BBB6 CRC64;
     MPMWAGGVGS PRRGMTPAST DDLFARKLRQ PARPPLTPHT FDPRPVRGPL LRSGSDAGEA
     RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA EEPEPAFPPV LEPRWFAHYD
     VQSLLFDWAP RSQGTGSHSE ASSGTLASAD HQAASSDLLH GAPGFVCELG GEGELGLGGP
     ASPPVPPALP NAAVSILEEP QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP
     VAVSLRREEK EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA
     PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM YNNQEAGPAF
     MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ DHEIMFHVST MLPYTPNNQQ
     QLLRKRHIGN DIVTIVFQEP GSKPFCPATI RSHFQHVFLV VRAHAPCTPH TSYRVAVSRT
     QDTPAFGPAL PAGGGPFAAN ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA
     TNEVTTTSLD SASRFGLPSL GGRRRAAPRG PGAELQAAGS LVWGVRAASG ARVAAGAQAS
     GPEGAEVPCL LGISAEALVL VAPRDGRVVF NCACRDVLAW TFSEQQLDLY HGRGEAITLR
     FDGSPSQAVG EVVARLQLVS RGCETRELAL PRDGQGRLGF EVDAEGFVTH VERFTFAETA
     GLRPGARLLR VCGQTLPSLR PEAAAQLLRS APKVCVTVLP PDESGRPRRS FSELYMLSLQ
     EPSRRGAPEP VQDEVQGVTL LPTTKQLLHL CLQDGGSPPA PGNLAEERTE FLHSQNSLSP
     RSSLSDEAPV LPNTTPDLLL ATTAKPSVPS ADSEAPLTQD GPGSPSGSED KGNPAPELRA
     SFLPRTLSLR NSISRIMSEA GSGTLEDEWQ AISEIASTCN TILESLSREG QPIPESGDPK
     GTPKSDAEPE PGNLSEKVSH LESMLRKLQE DLQKEKADRA ALEEEVRSLR HNNRRLQAES
     ESAATRLLLA SKQLGSPTAD LA
//