ID A0A0D9R6V1_CHLSB Unreviewed; 310 AA.
AC A0A0D9R6V1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Syndecan {ECO:0000256|RuleBase:RU000649};
GN Name=SDC1 {ECO:0000313|Ensembl:ENSCSAP00000004340.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004340.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004340.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004340.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cell surface proteoglycan. {ECO:0000256|RuleBase:RU000649}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
CC Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
CC -!- SIMILARITY: Belongs to the syndecan proteoglycan family.
CC {ECO:0000256|ARBA:ARBA00005343, ECO:0000256|RuleBase:RU000649}.
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DR EMBL; AQIB01032387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01032388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01032389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01032390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01032391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007969561.1; XM_007971370.1.
DR AlphaFoldDB; A0A0D9R6V1; -.
DR STRING; 60711.ENSCSAP00000004340; -.
DR Ensembl; ENSCSAT00000006131.1; ENSCSAP00000004340.1; ENSCSAG00000008077.1.
DR GeneID; 103220724; -.
DR KEGG; csab:103220724; -.
DR CTD; 6382; -.
DR eggNOG; ENOG502RZWT; Eukaryota.
DR GeneTree; ENSGT00940000161171; -.
DR OMA; STWKDMA; -.
DR OrthoDB; 5360052at2759; -.
DR BioGRID-ORCS; 103220724; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000008077; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0038024; F:cargo receptor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0048627; P:myoblast development; IEA:Ensembl.
DR GO; GO:1903543; P:positive regulation of exosomal secretion; IEA:Ensembl.
DR GO; GO:1903553; P:positive regulation of extracellular exosome assembly; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0055002; P:striated muscle cell development; IEA:Ensembl.
DR InterPro; IPR003585; Neurexin-like.
DR InterPro; IPR001050; Syndecan.
DR InterPro; IPR027789; Syndecan/Neurexin_dom.
DR InterPro; IPR030479; Syndecan_CS.
DR PANTHER; PTHR10915; SYNDECAN; 1.
DR PANTHER; PTHR10915:SF5; SYNDECAN-1; 1.
DR Pfam; PF01034; Syndecan; 1.
DR SMART; SM00294; 4.1m; 1.
DR PROSITE; PS00964; SYNDECAN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU000649};
KW Heparan sulfate {ECO:0000256|ARBA:ARBA00023207,
KW ECO:0000256|RuleBase:RU000649};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974,
KW ECO:0000256|RuleBase:RU000649};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000649};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..310
FT /note="Syndecan"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002344484"
FT TRANSMEM 252..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 275..293
FT /note="Neurexin/syndecan/glycophorin C"
FT /evidence="ECO:0000259|SMART:SM00294"
FT REGION 27..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 32476 MW; 974C34FD6125F9AC CRC64;
MRRAALWLWL CALALSLQPA MPQIVATNLP PEDQDGSGDD SDNFSGSGAG ALQDITLSQQ
TPSTWKDTWL LTATPTSPEP TGLEATAAST STLPAGEGPK EGEAVVLLEV EPGLTAREQE
ATPQPTETTQ LPTTHQAPTA RATTAQEPAT SHPHRDMQPG HHETSAPAGP GQADLHTPRT
EDGGPSATER AAEDGASSQL PAAEGSGEQD FTFETSGENT AIVAVEPDHR NQSPVDPGTT
GASQGLLDRK EVLGGIIAGG LVGLIFAVCL VGFMLYRMKK KDEGSYSLEE PKQANGGAYQ
KPTKQEEFYA
//
