ID A0A0D9R702_CHLSB Unreviewed; 450 AA.
AC A0A0D9R702;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Bifunctional apoptosis regulator {ECO:0000313|Ensembl:ENSCSAP00000004391.1};
GN Name=BFAR {ECO:0000313|Ensembl:ENSCSAP00000004391.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004391.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004391.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004391.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01118299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01118304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007984515.1; XM_007986324.1.
DR AlphaFoldDB; A0A0D9R702; -.
DR STRING; 60711.ENSCSAP00000004391; -.
DR Ensembl; ENSCSAT00000006186.1; ENSCSAP00000004391.1; ENSCSAG00000008131.1.
DR GeneID; 103228723; -.
DR KEGG; csab:103228723; -.
DR CTD; 51283; -.
DR eggNOG; KOG4159; Eukaryota.
DR GeneTree; ENSGT00390000005386; -.
DR OMA; GNDQMPT; -.
DR OrthoDB; 4047619at2759; -.
DR BioGRID-ORCS; 103228723; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 5.
DR Bgee; ENSCSAG00000008131; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0089720; F:caspase binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1903895; P:negative regulation of IRE1-mediated unfolded protein response; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR CDD; cd16497; RING-HC_BAR; 1.
DR CDD; cd09513; SAM_BAR; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR15898:SF21; BIFUNCTIONAL APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR15898; UNCHARACTERIZED; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..74
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 182..249
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 52851 MW; 8FD53266ACE0E03F CRC64;
MEEPQKNYLN TMDLEKDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL
WWASSKKTEC PECREKWEGF PKVNILLRDA IEKLFPDAIR MRFEDIQQNN DIVQSLAAFQ
KYGNDQIPLA PNTGRANQQR GGGFFSGVLT ALTGVAVVLL VYHWSSRESE HDLLVHKAVA
KWTAEEVVLW LEQLGPWASL YRERFLSERV NGRLLLTLTE EEFSKTPYTI ENSSHRRAIL
MELERVKALG MKPPQNLWEY KAVNPGRSLF LLYALKSSPR LGLLYLYLFD YTDTFLPFIH
TICPLQEDSS GEDIVTKLLD LKEPTWKQWR EFLVKYSFLP YQLIAEFAWD WLEVHYWTSR
FLIINAMLLS VLELFSFWRI WSRSELRTVP QRMWSHFWKV STQGLFVAMF WPLIPQFVCN
CLFYWALYFN PIINIDLVVK ELRRLETQVL
//
