ID A0A0D9R728_CHLSB Unreviewed; 783 AA.
AC A0A0D9R728;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Ras and Rab interactor 1 {ECO:0000313|Ensembl:ENSCSAP00000004417.1};
GN Name=RIN1 {ECO:0000313|Ensembl:ENSCSAP00000004417.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004417.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004417.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004417.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000256|ARBA:ARBA00006919}.
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DR EMBL; AQIB01078454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007974081.1; XM_007975890.1.
DR AlphaFoldDB; A0A0D9R728; -.
DR STRING; 60711.ENSCSAP00000004417; -.
DR Ensembl; ENSCSAT00000006210.1; ENSCSAP00000004417.1; ENSCSAG00000008180.1.
DR GeneID; 103223351; -.
DR KEGG; csab:103223351; -.
DR CTD; 9610; -.
DR eggNOG; KOG2320; Eukaryota.
DR GeneTree; ENSGT00940000161834; -.
DR OMA; CQGHEDA; -.
DR OrthoDB; 5483004at2759; -.
DR BioGRID-ORCS; 103223351; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000008180; Expressed in caudate nucleus and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF62; RAS AND RAB INTERACTOR 1; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 69..163
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 456..598
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 624..706
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..272
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 84624 MW; 27F6D77303D81A3A CRC64;
MESPGESGTG PPGAPSPSSF TPGHLETEKP AQDPLYDVPN ASGRQAGGPQ RPGRVVSLRE
RLLLTRPVWL QLQANAAAAL HVLRTEPPGT FLVRKSNTRH CQALCMRLPE ASGPSFVSSH
YILESPGGVS LEGSELMFPD LVQLICAYCH TRDILLLPLQ LPRAIHRAAT HKELEAISHL
GIEFWSSSLN IKAQRGPAGG PVLPQLKARS PQELDQGTGA ALCFFNPLFP GDLGPTKREK
FKRSFKVRVS TETSSPLSPP AVPPPPVPVL PGAVPSQTER LPPCQLLRRE SSVGYRVPAG
GDPSLPPMPS LQEVDCGSPS SSEEEGAPGS RGSPATSPHL GRRRPLLRSM SAAFCSLLAP
ERQVGRAAAA LMQDRHTAAG QLVQDLLTQV RAGPEPQELQ GIRQALSRAR AMLCVELGPE
KLLPPKRLEH VLEKSLHRSV LKPLRPILAA RVRRRLAADG SLGRLAEGLR LARAQGPGAF
GSHLSLPSPV EMEQVRQKLL QLLRTYSPSA QVKRLLQACK LLYMALRTQE GEDAGADEFL
PLLSLVLAHC DLPELLLEAE YMSELLEPSL LTGEGGYYLT SLSASLALLS GLGQAHTLPL
SPSQELRRSL SLWEQRRLPA THCFQHLLRV AYQDPSSGCT SKTLAVPPEA SIATLNQLCA
TKFRVTQPNT FGLFLYKDQG YHRLPPGALA HRLPTTGYLV YRRAEWPETQ EAATEEEGRG
QSEARSRGEE QGCQGDEDAG VKASPRDTRE ESETTAEGGQ GRVREGPAQS GEPEAEGSRA
AEE
//
