ID A0A0D9R8F3_CHLSB Unreviewed; 561 AA.
AC A0A0D9R8F3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Doublesex and mab-3 related transcription factor 2 {ECO:0000313|Ensembl:ENSCSAP00000004892.1};
GN Name=DMRT2 {ECO:0000313|Ensembl:ENSCSAP00000004892.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000004892.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000004892.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000004892.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family.
CC {ECO:0000256|ARBA:ARBA00006834}.
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DR EMBL; AQIB01021545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007967582.1; XM_007969391.1.
DR RefSeq; XP_007967583.1; XM_007969392.1.
DR AlphaFoldDB; A0A0D9R8F3; -.
DR STRING; 60711.ENSCSAP00000004892; -.
DR Ensembl; ENSCSAT00000006693.1; ENSCSAP00000004892.1; ENSCSAG00000008632.1.
DR KEGG; csab:103219528; -.
DR eggNOG; KOG3815; Eukaryota.
DR GeneTree; ENSGT00940000156282; -.
DR OMA; WDLKGTR; -.
DR BioGRID-ORCS; 103219528; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR GO; GO:0061055; P:myotome development; IEA:Ensembl.
DR GO; GO:2000287; P:positive regulation of myotome development; IEA:Ensembl.
DR GO; GO:0014807; P:regulation of somitogenesis; IEA:Ensembl.
DR Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR PANTHER; PTHR12322:SF53; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 2; 1.
DR Pfam; PF00751; DM; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00070}; Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT DOMAIN 123..170
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DNA_BIND 123..170
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..67
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 61946 MW; 629E2897F7DC997D CRC64;
MADPQAGLAA GDWEIDVESL ELEEDGCGAQ RSTPPEPSPP PADGDGEDDE DDDEVDEDAE
EEGDGEEAGA SPGMPGQPEQ QGGLQPRPPL APQASPAGTG PPERCTPAGG GAEPRKLSRT
PKCARCRNHG VVSCLKGHKR FCRWRDCQCA NCLLVVERQR VMAAQVALRR QQATEDKKGL
SGKQNNFERK TVYQRQVRAP SLLAKSILEG YRPIPAETYV GGTFPLPPPV SDRMRKRRAF
ADKELENIML EREYKEREML ETSQAAALFL PNRIVPGPDY NSYKSAYSPS PVEPQSKDFC
NFLPTCLDLT MQYSGSGNME LISSNVSVAT TYRQYPVSSR FLVWPKCGPI SDTLLYQQCL
LNATTSVQAL KPGASWDLKG ARVQDGLSAE HDMMPSKLEG SLVLPHTPEI QTTRSDLQGH
QAVPERSAFS PPRRNFSPVV DMDSLAAQGH VLTKISKENT RHPLPLRHNP FHSLFQHTLN
DKSGPELKTP FVKEAFEETP KKHRECLVKE NQKYTFTIDR CAKDLFVAKQ VGTKLSVNEP
LSFSVESILK RPSSAITRVS Q
//
