ID A0A0D9R9Q5_CHLSB Unreviewed; 429 AA.
AC A0A0D9R9Q5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Sterile alpha motif domain containing 8 {ECO:0000313|Ensembl:ENSCSAP00000005344.1};
GN Name=SAMD8 {ECO:0000313|Ensembl:ENSCSAP00000005344.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000005344.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000005344.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000005344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; AQIB01043389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007961119.1; XM_007962928.1.
DR AlphaFoldDB; A0A0D9R9Q5; -.
DR STRING; 60711.ENSCSAP00000005344; -.
DR Ensembl; ENSCSAT00000007156.1; ENSCSAP00000005344.1; ENSCSAG00000009093.1.
DR eggNOG; KOG3058; Eukaryota.
DR GeneTree; ENSGT00940000155540; -.
DR OMA; GADWLCN; -.
DR OrthoDB; 1343173at2759; -.
DR BioGRID-ORCS; 103215966; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 9.
DR Bgee; ENSCSAG00000009093; Expressed in Ammon's horn and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0002950; F:ceramide phosphoethanolamine synthase activity; IEA:Ensembl.
DR GO; GO:0046513; P:ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:1905373; P:ceramide phosphoethanolamine biosynthetic process; IEA:Ensembl.
DR GO; GO:2000303; P:regulation of ceramide biosynthetic process; IEA:Ensembl.
DR CDD; cd09515; SAM_SGMS1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 167..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..92
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 429 AA; 49916 MW; E39FD81BE37CDF96 CRC64;
MGVTWNPLVA VEEEMAGHNQ LCIRRWTTKH VAVWLKDEGF FEYVDILCNK HRLDGITLLT
LTEYDLRSPP LEIKVLGDIK RLMLSVRKLQ KIHIDVLEEM GYNSDSPMGS MTPFISALQS
TDWLCNGELS HDCDGPITDL NSDQYQYMNG KNKHSVRRLD PEYWKTILSC IYVFIVFGFT
SFIMVIVHER VPDMQTYPPL PDIFLDSVPR IPWAFAMTEV CGMILCYIWL LVLLLHKHRS
ILLRRLCSLM GTVFLLRCFT MFVTSLSVPG QHLQCTGKIY GSVWEKLHRA FAIWSGFGMT
LTGVHTCGDY MFSGHTVVLT MLNFFVTEYT PRSWNFLHTL SWVLNLFGIF FILAAHEHYS
IDVFIAFYIT TRLFLYYHTL ANTRAYQQSR RARIWFPMFS FFECNVNGTV PNEYCWPFSK
PAIMKRLIG
//
