ID A0A0D9R9V4_CHLSB Unreviewed; 1833 AA.
AC A0A0D9R9V4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Plexin D1 {ECO:0000313|Ensembl:ENSCSAP00000005393.1};
GN Name=PLXND1 {ECO:0000313|Ensembl:ENSCSAP00000005393.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000005393.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000005393.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000005393.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AQIB01143981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000005393; -.
DR Ensembl; ENSCSAT00000007210.1; ENSCSAP00000005393.1; ENSCSAG00000009144.1.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR OMA; GHLCMWS; -.
DR Proteomes; UP000029965; Chromosome 22.
DR Bgee; ENSCSAG00000009144; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0044297; C:cell body; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0003279; P:cardiac septum development; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IEA:Ensembl.
DR GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0045765; P:regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR GO; GO:0008039; P:synaptic target recognition; IEA:Ensembl.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12788; RasGAP_plexin_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1094..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..368
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1833 AA; 203152 MW; 53C4264136ECF4E9 CRC64;
MLNVAANHPN ASTVGLVLPP AAGAGGSRLL VGATYTGYGS SFFPRNRSLE DHRFENTPEI
AIRSLDARGD LAKLFTFDLN PSDDNILKIK QGAKEQHKLG FVSAFLHPPD PPPGAQPYAY
LALNSEARAG DKESQARSLL ARICLPHGAG SDAKKLTESY IQLGLQCAGG AGRGDLYSRL
VSVFPARERL FAVFERPQGS PAARAAPAAL CAFRFADVRA AIRAARTACF VEPAPDVVAV
LDSVVQGTGP ACERKRNIQL QPEQLDCGAA HLQHPLSILQ PLKATPVFRA PGLTSVAVAS
VNNYTAVFLG TVNGRLLKIN LNESMQVVSR RVVTVAYGEP VHHVMQFDPA DSGYLYLMTS
HQMARVKVAA CNVHSTCGDC VGAADAYCGW CALETRCTLQ QDCANSSQQH FWTSASEGPS
RCPAMTVLPA EIDVRQEYPG MILQISGSLP SLSGMEMACD YGKNIRTVAR VPGPAFGHQI
AYCNLLPRDR FPPFPPNQDH MTVEMSVRVN GRNIVKANFT IYDCSRTAQV YPHTACTSCL
SAQWPCFWCS QQHSCVSNQS RCEASPNPTS PQDCPRTLLS PLAPVPTGGS QNILVPLANA
AFFQGAALEC SFGLEEIFEA VWVNESVVRC DQVVLHTTQK SQVFPLSLQL KGRPARFLDS
PEPMTVVVYN CAMGSPDCSQ CLGREDLGHL CVWSDGCRLR GPLQPMPGTC PAPEIRAIEP
LSGPLDGGTL LTIRGRNLGR RLSDVAHGVW IGGVACEPLP DRYTVSEEIV CVTGPAPGPL
SDIVTVNASK EGKSRDRFSY VLPLVHSLEP PMGPKAGGTR ITIHGNDLHV GSELQVLVND
TDPCTELMRT DTSITCTVPE GALPAPVPVC VRFERQGCVH GNLTFWYMQN PVITAISPRR
SPVSGGRTIT VAGERFHMVQ NVSMAVHHIG REPTLCKVLN STLITCPSPG ALSNASAPVD
FFINGRAYAD EVAVTEELLD PEEAQRGSRF RLDYLPNPQF STAKREKWIK HHPGEPLTLV
IHKEQDSLGL QSHEYRVKIG QVSCDIQIVS DRIIHCSVNE SLGAAEGQLP ITIQVGNFNQ
TIATLQLGGS ETAIIVSIVI CSVLLLLSVV ALFIFCTKSR RAERYWQKTL LQMEEMESQI
REEIRKGFAE LQTDMTDLTK ELNRSQGIPF LEYKHFVTRT FFPKCSSLYE ERYVLPSQTL
NSQGSSQAQE THPLLGEWKI PESCRPNMEE GISLFSSLLN NKHFLIVFVH ALEQQKDFAV
RDRCSLASLL TIALHGKLEY YTSIMKELLV DLIDASAAKN PKLMLRRTES VVEKMLTNWM
SICMYSCLRE TVGEPFFLLL CAIKQQINKG SIDAITGKAR YTLNEEWLLR ENIEAKPRNL
NVSFQGCGMD SLSVRAMDTD TLTQVKEKIL EAFCKNVPYS QWPRAEDVDL EWFASSTQSY
ILRDLDDTSV VEDGRKKLNT LAHYKIPEGA SLAMSLIDKK DNTLGRVKDL DTEKYFHLVL
PTDELAEPKK SHRQSHRKKV LPEIYLTRLL STKGTLQKFL DDLFKAILSI REDKPPLAVK
YFFDFLEEQA EKRGISDPDT LHIWKTNSLP LRFWVNILKN PQFVFDIDKT DHIDACLSVI
AQAFIDACSI SDLQLGKDSP TNKLLYAKEI PEYRKIVQRY YKQIQDMTPL SEQEMNAHLA
EESRKYQNEF NTNVAMAEIY KYAKRYRPQI MAALEANPTA RRTQLQHKFE QVVALMEDNI
YECYTSSWSC CREPCASRRP STKKGRGGHQ PGGCSPETLP HPHWCREPSL NRPLIGFCFN
PQNVISTSPS PKEDPGHRQF QVVSDFCCLG GCW
//
