ID A0A0D9RBM8_CHLSB Unreviewed; 737 AA.
AC A0A0D9RBM8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA-binding protein RFX2 {ECO:0000256|ARBA:ARBA00039910};
DE AltName: Full=Regulatory factor X 2 {ECO:0000256|ARBA:ARBA00042136};
GN Name=RFX2 {ECO:0000313|Ensembl:ENSCSAP00000006017.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000006017.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000006017.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000006017.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01153319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01153320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01153321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01153322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01153323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01153324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RBM8; -.
DR STRING; 60711.ENSCSAP00000006017; -.
DR Ensembl; ENSCSAT00000007855.1; ENSCSAP00000006017.1; ENSCSAG00000009771.1.
DR eggNOG; KOG3712; Eukaryota.
DR GeneTree; ENSGT01050000244879; -.
DR OMA; QFIDMSH; -.
DR Proteomes; UP000029965; Chromosome 6.
DR Bgee; ENSCSAG00000009771; Expressed in fibroblast and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619:SF17; DNA-BINDING PROTEIN RFX2; 1.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 199..274
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 81464 MW; E08127209CE8A67B CRC64;
MQNSEGGADS PASVALRPSA AAPPVPASPQ RVLVQAASSA PKGAQMQPIS LPRVQQVPQQ
VQPAQHVYPA QVQYVEGGDA VYTNGAIRTA YTYNPEPQMY APSSAASYFE APGGAQVTVA
ASSPPAVPSH SMVGITMDVG GSPIVSSTGA YLIHGGMDST RHSLAHTSRS SPATLEMAIE
NLQKSEGITS HKSGLLNSHL QWLLDNYETA EGVSLPRSSL YNHYLRHCQE HKLDPVNAAS
FGKLIRSVFM GLRTRRLGTR GNSKYHYYGI RLKPDSPLNR LQEDTQYMAM RQQPMHQKPS
ILGKPRYPPL LRMRYRPAQK TDSLGDSGSH SSLHSTPEQT MAAQSQHHQQ YIDVSHVFPE
FPAPDLGSVL LQDGVTLHDV KALQLVYRRH CEATVDVVMN LQFHYIEKLW FSFWNSKASS
SDGPTSLPAS DEDPEGAVLP KDKLISLCQC DPILRWMRSC DHILYQALVE ILIPDVLRPV
PSTLTQGIRN FAKSLEGWLT NAMGDFPQQV IQTKVGVVSA FAQTLRRYTS LNHLAQAARA
VLQNTSQINQ MLSDLNRVDF ANVQEQASWV CQCEESVVQR LEQDFKLTLQ QQSSLDQWAS
WLDSVVTQVL KQHAGSPSFP KAARQFLLKW SFYSSMVIRD LTLRSAASFG SFHLIRLLYD
EYMFYLVEHR VAEATGETPI AVMGEFNDLA SLSLTLLDKD DMGDEQRGSE AGPDAHSLGE
PLVKRERSDP NHSLQGI
//
