ID A0A0D9RCN1_CHLSB Unreviewed; 1320 AA.
AC A0A0D9RCN1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Slit guidance ligand 3 {ECO:0000313|Ensembl:ENSCSAP00000006370.1};
GN Name=SLIT3 {ECO:0000313|Ensembl:ENSCSAP00000006370.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000006370.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000006370.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000006370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01044622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01044623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000006370; -.
DR Ensembl; ENSCSAT00000008220.1; ENSCSAP00000006370.1; ENSCSAG00000010139.1.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000159322; -.
DR OMA; PACNANS; -.
DR Proteomes; UP000029965; Chromosome 23.
DR Bgee; ENSCSAG00000010139; Expressed in fibroblast and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048495; F:Roundabout binding; IEA:Ensembl.
DR GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
DR GO; GO:0061364; P:apoptotic process involved in luteolysis; IEA:Ensembl.
DR GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
DR GO; GO:0048846; P:axon extension involved in axon guidance; IEA:Ensembl.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
DR GO; GO:0050919; P:negative chemotaxis; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0051414; P:response to cortisol; IEA:Ensembl.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR PANTHER; PTHR45836:SF9; SLIT HOMOLOG 3 PROTEIN; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 2.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 9.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 715..750
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 752..791
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 793..829
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 831..869
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 871..907
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 916..952
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 955..1129
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1165..1200
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1205..1241
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1246..1320
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 740..749
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 781..790
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 819..828
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 859..868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 897..906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 942..951
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1102..1129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 1169..1179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1190..1199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1209..1219
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1231..1240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1320 AA; 145163 MW; 146F9770E365C266 CRC64;
MPKIRTLRLH SNHLYCDCHL AWLSDWLRQR RTVGQFTLCM APVHLRGFNV ADVQKKEYVC
PAPHSEPPSC NANSISCPSP CTCSNNIVDC RGKGLTEIPA NLPEGIVEIR LEQNSIKSIP
AGAFTQYKKL KRIDISKNQI SDIAPDAFQG LKSLTSLVLY GNKITEIAKG LFDGLVSLQL
LLLNANKINC LRVNTFQDLQ NLNLLSLYDN KLQTISKGLF APLQSIQTLH LAQNPFVCDC
HLKWLADYLQ DNPIETSGAR CSSPRRLANK RISQIKSKKF RCSGSEDYRS RFSSECFMDL
VCPEKCRCEG TIVDCSNQKL ARIPSHLPEY VTDLRLNDNE ISVLEATGIF KKLPNLRKIN
LSNNKIKEVR EGAFDGAASV QELMLTGNQL ETVHGRMFRG LSGLKTLMLR SNSISCVSND
TFAGLSSVRL LSLYDNRITT ITPGAFTTLV SLSTINLLSN PFNCNCHLAW LGKWLRKRRI
VSGNPRCQKP FFLKEIPIQD VAIQDFTCDG NDESSCQLSP RCPEQCTCVE TVVRCSNKGL
RALPKGMPKD VTELYLEGNH LTAVPRELSA LRHLTLIDLS NNSISTLTNY TFSNMSHLST
LILSYNRLRC IPVHAFNGLR SLRVLTLHGN DISSVPEGSF NDLTSLSHLA LGTNPLHCDC
SLRWLSEWVK AGYKEPGIAR CSSPEPMADR LLLTTPTHRF QCKGPVDINI AAKCNACLSS
PCKNNGTCTQ DPVELYRCAC PYSYKGKDCT VPINTCIQNP CQHGGTCHLS DSHKDGFSCS
CPLGFEGQRC EINPDDCEDN DCENNATCVD GINNYVCVCP PNYTGELCDE VIDHCVPELN
LCQHEAKCIP LDKGFRCECV PGYSGKLCET DNDDCVAHKC RHGAQCMDTI NGYTCTCPQG
FSGPFCEHPP PMVLLQTSPC DQYECQNGAQ CIVVQQEPTC RCPPGFAGPR CEKLITVNFV
GKDSYVELAS AKVRPQANIS LQVATDKDNG ILLYKGDNDP LALELYQGHV RLVYDSLSSP
PTTVYSVETV NDGQFHSVEL VMLNQTLNLV VDKGTPKSLG KLQKQPAVGI NSPLYLGGIP
TSTGLSALRQ GTDRPLGGFH GCIHEVRINN ELQDFKALPP QSLGVSPGCK SCTVCKHGLC
RSVEKDSVVC ECHPGWTGPL CDQEARDPCL GHSCNHGKCV ATGTSYMCKC AEGYGGALCD
NKNDSANACS AFKCHHGQCH ISDQGEPYCL CQPGFSGEHC QQENPCLGQV VREVIRRQKG
YASCATASKV PIMECHGGCG PQCCQPTRSK RRKYVFQCTD GSSFVEEVER HLECGCLGCS
//
