ID A0A0D9RD88_CHLSB Unreviewed; 2262 AA.
AC A0A0D9RD88;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Collagen type VI alpha 6 chain {ECO:0000313|Ensembl:ENSCSAP00000006577.1};
GN Name=COL6A6 {ECO:0000313|Ensembl:ENSCSAP00000006577.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000006577.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000006577.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000006577.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR EMBL; AQIB01076382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01076383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008007355.1; XM_008009164.1.
DR RefSeq; XP_008007356.1; XM_008009165.1.
DR RefSeq; XP_008007357.1; XM_008009166.1.
DR RefSeq; XP_008007358.1; XM_008009167.1.
DR STRING; 60711.ENSCSAP00000006577; -.
DR Ensembl; ENSCSAT00000008434.1; ENSCSAP00000006577.1; ENSCSAG00000010431.1.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000155619; -.
DR OMA; NFIRNTS; -.
DR OrthoDB; 5359724at2759; -.
DR BioGRID-ORCS; 103241696; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 15.
DR Bgee; ENSCSAG00000010431; Expressed in liver.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR CDD; cd01472; vWA_collagen; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 8.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00092; VWA; 8.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2262
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002345009"
FT DOMAIN 28..207
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 230..412
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 437..607
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 623..792
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 810..983
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1001..1172
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1188..1380
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1758..1903
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1966..2167
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1398..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2262 AA; 246911 MW; 49E197F2D843EAE7 CRC64;
MKMLLILFLM IICSHISVSQ DSGPKYADVV FLVDSSDRLG SRSFPFVKMF ITKMINSLPI
EADKYRVGLA QYSDKLHSEF HLSTFKGRSP MLNHLKKNFG FIGGSLQIGK ALQEAHRTYF
SATTNGRDKK QFPPILVVLA SSESEDDVEE ASKALQKDGV KIISIGVQKA SEENLKAMAT
SQFHFNLRTV RDLSMFSQNM THIIKDVAKY KEGAVDDIFV EACQGPSMAD VVFLLDMSIN
GSDENLDYLK GFLEESVSAL DIKENCMRIG LVAYSNETKV INSLSMGINK SEVLQHIQNL
SPRTGKAYTG AAIKKLRKEV FSARNGSRKN QGVPQIAVLV THRDSEDNVT KAAVNLRREG
VTIFTLGIKG ASDTQLEKIA SHPAEQYVSK LKTFADLAAH NQTFLKKLRN QITHTVSVFS
ERTETLKSGC VDTEEADIYL LIDGSGSTQA TDFHEMKIFL SEVVGMFNIA PHKVRVGAVQ
YADSWDLEFE INKYSNKQDL GKAIENIRQM GGNTNTGAAL NFTLSLLQKA KKQRGNKVPC
HLVVLTNGMS KDSILEPANR LREEHIRVYA IGIKAANQTQ LREIAGEEKR VYYVHDFDAL
KDIRNQVVQE ICAEEACKEM KADIMFLVDS SGSIGPENFS KMKTFMKNLV SKSQIGPDRV
QIGVVQFSDI NKEEFQLNRF MSQSDISNAI DQMAHIGQTT LTGSALSFVS QYFSPTKGAR
PNVRKFLILI TDGEAQDIVK EPAVVLRQKG VIIYSVGVFG SNVTQLEEIS GRPEMVFYVE
NFDILQRIED DLVFGICSPR EECKRIEVLD VVFVIDSSGS IDYDEYNIMK DFMIDIVRKA
DVGMNRVRFG ALKYADDPEV LFYLDNFGTK PEVISVLQND QAMGGNTYTA EALGFSDHMF
TEARGSRLNK GVPQVLIVIT DGDSHDADKL NATAKALRDK GILVLAVGIA DANPVELLAM
AGSSDKYFFV ETFGGLKGII SDVTASVCNS SKVDCEIDKV DLVFLMDGST SIQQTDFKKM
KEFLVSVVQD FDVSPNRVRI GAAQFSDAYR PEFPLGTFIG AKEISIQIEN ITQIFGNTHI
GAALRKVEHY FRPDMGSRIN TGTPQVLLVL TDGQSQDEVA QAAEALRRRG IDIYSVGIGD
VDDQQLMQIT GTAEKKLTVH NFDELKKVNK RIVRNICTTG GESNCFMDVV VGFDVSTQEK
GQTLLEGQPW METYLQDILR AISSLNGVSC EVGTETQVSV AFQVTNAMEK YSPKFEIYSE
NILNSLKDIT VKGPSFLNAN LLDSLWDTFQ NKSAARGKVV LLFSDGLDDD AEKLEQKSDE
LRKEGLNALI TVALDGPADS SDLADLPYIE FGKGFEYRTQ LSIGMRDLGS RLSKQLVNVA
ERTCCCLFCK CIGGDGTMGD PGPPGKRGPP GFKGSEGYLG EEGIAGERGA PGPVGEQGTK
GCYGTKGPKG NRGLNGQEGE AGESGIDGLN GEQGDYGLPG RKGEKGDEGS QGSPGKRGIP
GDHGAKGLRG DPGAPGVDNS IEGPTGLKGE RGREGRRGWP GPPGTPGSRR RTAAHGRRGH
TGPQGTAGIP GPDGLEGSLG LKGPQGPRGE AGVKGEKGGV GSKGPQGAPG PGGEAGNQGH
LGSQGNKGEP GDLGEKGAVG FPGPRGLQGD DGSPGYGSVG RKGAKGQGGF PGESGPKGEI
GDPGGPGETG LKGARGKTIS AGLPGEMGSP GEPGPPGRKG VKGAKGLASF STCELIQYVR
DRSPGRRGKL ECPVHPTELV FALDQSRDVT EREFERMKEM MAFLVKDIKV RENSCPVGAR
IAILSYNSHA RHLVRFSDAY KKNQLLREIK AIPYERSPSS REIGRAMRFI SRNVFKRTLP
GAHTRRIATF FSSGQSADSQ SITTAAMEFS ALEIIPVVIT FSNVPSVRRA FAIDDTGTFQ
VIVVPSGADY IPALERLQRC TFCYDVCKPD ASCDQARPPP VQSYMDAAFL LDGSRNVGSA
EFEDIRAFLG ALLDHFEITP EPETSVTGDR VALLSHAPPD FLPNTQKSPV RAEFNLTTYS
SKRLMKRHVD ESVKQLNGDA FIGHALQWTL DNVFLTAPNL RRNKVIFVIS AGETSHLDGE
ILKKESLRAK CQGYALFVFS LGPTWDDKEL EDLASHPLDH HLVQLGRIHK PDHSYGVKFV
KTFINSIRRA INKYPPINLK IKCNRLNSAD PRQPPRHFRS FVPGPYKATL KEDVLQKATF
FQDKKYLSRV ARSGRDDAFQ NFIRNTSHTF KNGRRVTKSA PK
//
