ID A0A0D9REW8_CHLSB Unreviewed; 280 AA.
AC A0A0D9REW8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Transcription factor EC {ECO:0000256|ARBA:ARBA00019430};
GN Name=TFEC {ECO:0000313|Ensembl:ENSCSAP00000007157.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000007157.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000007157.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000007157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR EMBL; AQIB01019048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01019049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007980860.1; XM_007982669.1.
DR AlphaFoldDB; A0A0D9REW8; -.
DR STRING; 60711.ENSCSAP00000007157; -.
DR Ensembl; ENSCSAT00000009027.1; ENSCSAP00000007157.1; ENSCSAG00000010942.1.
DR GeneID; 103226765; -.
DR CTD; 22797; -.
DR eggNOG; KOG1318; Eukaryota.
DR GeneTree; ENSGT00940000159404; -.
DR OMA; STEWHLS; -.
DR OrthoDB; 3061893at2759; -.
DR BioGRID-ORCS; 103226765; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 21.
DR Bgee; ENSCSAG00000010942; Expressed in blood and 2 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd18925; bHLHzip_TFEC; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF1; TRANSCRIPTION FACTOR EC; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 72..125
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 253..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 125..159
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 253..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 31572 MW; 2D72FE602EBEC480 CRC64;
MMKETEKTIA IVKVIDTSKL KLLSGSILDV YSGEQGISPI NMGLTSASCP SSLPMKREIT
ETDTRALAKE RQKKDNHNLI ERRRRYNINY RIKELGTLIP KSNDPDMRWN KGTILKASVE
YIKWLQKEQQ RARELEHRQK KLEQANRRLL LRIQELEIQA RTHGLPTLAS LGTVDLGAHV
TKQQSHPEQN SVDYCQQLTV SQGPTPELCD QAIAFSDPLS YFTDLSFSAA LKEEQRLDGM
LLDDTISPFG TDPLLSATSP AVSKESSRRN SFSSDDGDEL
//
