ID A0A0D9RFE1_CHLSB Unreviewed; 895 AA.
AC A0A0D9RFE1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Inversin {ECO:0000313|Ensembl:ENSCSAP00000007330.1};
GN Name=INVS {ECO:0000313|Ensembl:ENSCSAP00000007330.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000007330.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000007330.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000007330.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AQIB01022160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01022161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01022162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01022163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01022164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01022165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01022166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007966780.1; XM_007968589.1.
DR AlphaFoldDB; A0A0D9RFE1; -.
DR STRING; 60711.ENSCSAP00000007330; -.
DR Ensembl; ENSCSAT00000009203.1; ENSCSAP00000007330.1; ENSCSAG00000011117.1.
DR GeneID; 103219130; -.
DR CTD; 27130; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000157688; -.
DR OMA; DGHWKPS; -.
DR OrthoDB; 5474520at2759; -.
DR BioGRID-ORCS; 103219130; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 12.
DR Bgee; ENSCSAG00000011117; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR24178:SF2; INVERSIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00612; IQ; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 15.
DR SMART; SM00015; IQ; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 10.
DR PROSITE; PS50088; ANK_REPEAT; 11.
DR PROSITE; PS50096; IQ; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 47..79
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 80..112
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 148..180
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..240
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 254..286
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 288..320
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 356..388
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 389..421
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 422..454
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 455..487
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 488..520
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 589..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 99726 MW; 38F8DAB1E65559C1 CRC64;
MNKSENLLFA RSSLASQVHA AAVNGDKGAL QRLIAGNSAL KDKEDQFGRT PLMYCVLADR
LDCADALLKA GADVNKTDHS QRTALHLAAQ KGNYRFVKLL LTRRANWMQK DLEEMTPLHL
TTRHRSPKCL ALLLKFMAPG EVDTQDKNKQ TALHWSAYYN NPEHVKLLIK HDSNIGIPDV
EGKIPLHWAA NHKDPSAVHT VRCILDAAPT ESLLNWQDYE GRTPLHFAVA DGNVTVVDVL
TSYESCNITS YDNLFRTPLH WAALLGHAQI VHLLLERNKS GTIPSDSQGA TPLHYAAQSN
FAETVKVFLK HPSVKDDSDL EGRTSFMWAA GKGSDDVLRT MLSLKSDIDI NMADKYGGTA
LHAAALSGHV STVKLLLENN AQVDATDVMK HTPLFRACEM GHKDVIQTLI KGGARVDLVD
QDGHSLLHWA ALGGNADVCQ ILIENKINPN VQDYAGRTPL QCAAYGGYIN CMAVLMENNA
DPNIQDKEGR TALHWSCNNG YLDAIKLLLD FAAFPNQMEN NEERYTPLDY ALLGERHEVI
QFMLEHGALS IAAIQDIAAF KIQAVYKGYK VRKAFRDRKN LLMKHEQLRK DAAAKKREEE
NKRKEAEQQK GRQSPDSCRP QALPCLPSTQ DAPSRQSRAP SKQPPAGNVA QGPEPRDSRG
SPGGSLGRAL QKEQYTSLDL QGTNSRRPNE TAREHSKGQS ACVHFRPNEG SDGNRHPGVP
SVEKSRELRL QIIQRERRRK ELFRKKNKAA AVIQRAWRSY QLRKHLSHLR HTKQLGAGDV
DRWRQKCTAL LLQIWRKELE LKLPQTTAVS KTPKNPSKGT SGTKSTKHSV LKQIYGCSQE
GKIHHPTRSV KASSVLRLNS VSNLQCIHLL DNSGRSKNFS YNLQSATQPK NKTKP
//
