ID A0A0D9RFL0_CHLSB Unreviewed; 343 AA.
AC A0A0D9RFL0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Nuclear transcription factor Y subunit {ECO:0000256|RuleBase:RU367155};
GN Name=NFYA {ECO:0000313|Ensembl:ENSCSAP00000007399.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000007399.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000007399.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000007399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC box motif found in the promoters of its target genes.
CC {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBUNIT: Heterotrimer. {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367155}.
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000256|RuleBase:RU367155}.
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DR EMBL; AQIB01159891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RFL0; -.
DR STRING; 60711.ENSCSAP00000007399; -.
DR Ensembl; ENSCSAT00000009274.1; ENSCSAP00000007399.1; ENSCSAG00000011196.1.
DR eggNOG; KOG1561; Eukaryota.
DR GeneTree; ENSGT00390000015714; -.
DR OMA; VAHMIRV; -.
DR Proteomes; UP000029965; Chromosome 17.
DR Bgee; ENSCSAG00000011196; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0035065; P:regulation of histone acetylation; IEA:Ensembl.
DR Gene3D; 6.10.250.2430; -; 1.
DR InterPro; IPR018362; CCAAT-binding_factor_CS.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632:SF6; NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA; 1.
DR PANTHER; PTHR12632; TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR PRINTS; PR00616; CCAATSUBUNTB.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS00686; NFYA_HAP2_1; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU367155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367155};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367155};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU367155}.
FT REGION 296..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 343 AA; 36507 MW; B9902F0408832E55 CRC64;
MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ TLQVVVQGQP
LMVQVSGGQL ITSTGQPIMV QAVPGGQGQT IMQVPVSGTQ GLQQQIQLVP PGQIQIQGGQ
AVQVQGQQGQ TQQIIIQQPQ TAVTAGQSQT QQQIAVQGQQ VAQTAEGQTI VYQPVNADGT
ILQQGMITIP AASLAGAQIV QTGANTNTTS SGQGTVTVTL PVAGNVVNSG GMVMMVPGAG
SVPAIQRIPL PGAEMLEEEP LYVNAKQYHR ILKRRQARAK LEAEGKIPKE RRKYLHESRH
RHAMARKRGE GGRFFSPKEK DSPHMQDPNQ ADEEAMTQII RVS
//
