ID A0A0D9RFW4_CHLSB Unreviewed; 161 AA.
AC A0A0D9RFW4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 20 {ECO:0000256|ARBA:ARBA00019690, ECO:0000256|RuleBase:RU364152};
DE AltName: Full=Mediator complex subunit 20 {ECO:0000256|RuleBase:RU364152};
GN Name=MED20 {ECO:0000256|RuleBase:RU364152,
GN ECO:0000313|Ensembl:ENSCSAP00000007503.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000007503.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000007503.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000007503.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687,
CC ECO:0000256|RuleBase:RU364152}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
CC {ECO:0000256|RuleBase:RU364152}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364152}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC {ECO:0000256|ARBA:ARBA00010743, ECO:0000256|RuleBase:RU364152}.
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DR EMBL; AQIB01159904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01159905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01159906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01159907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RFW4; -.
DR STRING; 60711.ENSCSAP00000007503; -.
DR Ensembl; ENSCSAT00000009386.1; ENSCSAP00000007503.1; ENSCSAG00000011299.1.
DR eggNOG; KOG4309; Eukaryota.
DR GeneTree; ENSGT00390000002060; -.
DR OMA; QSTFSIC; -.
DR Proteomes; UP000029965; Chromosome 17.
DR Bgee; ENSCSAG00000011299; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0070847; C:core mediator complex; IEA:Ensembl.
DR GO; GO:0016592; C:mediator complex; IEA:Ensembl.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR InterPro; IPR013921; Mediator_Med20.
DR PANTHER; PTHR12465:SF0; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20; 1.
DR PANTHER; PTHR12465; UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49; 1.
DR Pfam; PF08612; Med20; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364152};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364152};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transcription {ECO:0000256|RuleBase:RU364152};
KW Transcription regulation {ECO:0000256|RuleBase:RU364152}.
SQ SEQUENCE 161 AA; 17717 MW; B97D717008A91FA3 CRC64;
SLSLAGQTGK LMYVMHNSEY PLSCFALFEN GPCLIADTNF DVLMVKLKGF FQSAKASKIE
TRGTRYQYCD FLVKVGTVTM GPSARGISVE VEYGPCVVAS DCWSLLLEFL QSFLGSHTPG
APAVFGNRHD AVYGPADTMV QYMELFNKIR KQQQVPVAGI R
//
