ID A0A0D9RG25_CHLSB Unreviewed; 495 AA.
AC A0A0D9RG25;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Sex hormone-binding globulin {ECO:0000256|ARBA:ARBA00040510};
DE AltName: Full=Sex steroid-binding protein {ECO:0000256|ARBA:ARBA00041855};
DE AltName: Full=Testis-specific androgen-binding protein {ECO:0000256|ARBA:ARBA00041528};
GN Name=SHBG {ECO:0000313|Ensembl:ENSCSAP00000007564.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000007564.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000007564.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000007564.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an androgen transport protein, but may also be
CC involved in receptor mediated processes. Each dimer binds one molecule
CC of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
CC 17-beta-estradiol. Regulates the plasma metabolic clearance rate of
CC steroid hormones by controlling their plasma concentration.
CC {ECO:0000256|ARBA:ARBA00037620}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR EMBL; AQIB01138127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008008368.1; XM_008010177.1.
DR AlphaFoldDB; A0A0D9RG25; -.
DR STRING; 60711.ENSCSAP00000007564; -.
DR Ensembl; ENSCSAT00000009449.1; ENSCSAP00000007564.1; ENSCSAG00000011359.1.
DR GeneID; 103242318; -.
DR KEGG; csab:103242318; -.
DR CTD; 6462; -.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT00940000154035; -.
DR OMA; FPLMQIS; -.
DR OrthoDB; 5316510at2759; -.
DR BioGRID-ORCS; 103242318; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000011359; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24040:SF3; SEX HORMONE-BINDING GLOBULIN; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665}.
FT DOMAIN 138..310
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
SQ SEQUENCE 495 AA; 54289 MW; AC02C951DC6440A8 CRC64;
MEYPLPVQKF SRQWRMIVEG TLSFTPLIPR GVVAGSCDWA PGQGSRVSAP VSFTPSPRAT
FNPPPPTHKA ACLYTFSQEL SEPPSGQWLI MESRGPMATS RRLLWLLLLL LHHTHQGWAL
RPVLPTQRAQ DPPAVHLSNG PGLEPAAVMT FDLTKITNPS RTSSSFEVRT WDPEGVIFYG
DTNPKDDWFM LGLRDGRPEI QLHNYWAQLT VGAGPRLDDG RWHQVEVKMY GDSVLLKVDG
EEVLRLRQVS GPLTSKRHPI MRIALGGLLF PSSNLRLPLV PALDGCLRRD SWLDKQAEIS
ASAPTSLRSC DVESNPGIFL PPGTHAEFSL RDIPQPHAEP WAFSLDLGLK QAAGSGHLLS
LGTPENPSWL SLHLQDQKVV LSSGSGPEMD LPLVLGLPLQ LKLSMSRVVL SQGPKMEVLA
LPPLGLASLL NLWAKPQGRL FLGALPGEDS STSFCLHGLW AQGQRLDVDQ ALNRSHEIWT
HSCPQSPGNG TDASH
//
