ID A0A0D9RH00_CHLSB Unreviewed; 1012 AA.
AC A0A0D9RH00;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Zinc finger and BTB domain containing 4 {ECO:0000313|Ensembl:ENSCSAP00000007889.1};
GN Name=ZBTB4 {ECO:0000313|Ensembl:ENSCSAP00000007889.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000007889.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000007889.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000007889.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01138114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01138115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008008342.1; XM_008010151.1.
DR RefSeq; XP_008008343.1; XM_008010152.1.
DR AlphaFoldDB; A0A0D9RH00; -.
DR STRING; 60711.ENSCSAP00000007889; -.
DR Ensembl; ENSCSAT00000009781.1; ENSCSAP00000007889.1; ENSCSAG00000011692.1.
DR GeneID; 103242304; -.
DR KEGG; csab:103242304; -.
DR CTD; 57659; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161268; -.
DR OMA; VIAFAHP; -.
DR BioGRID-ORCS; 103242304; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000011692; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0008327; F:methyl-CpG binding; IEA:Ensembl.
DR GO; GO:0010428; F:methyl-CpNpG binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394:SF29; GM08392P; 1.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 30..152
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 234..262
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 309..336
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 337..364
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 365..388
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 725..752
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 764..791
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 67..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..474
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..533
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..656
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..996
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 104759 MW; 72816743A2544369 CRC64;
MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL
TSAPLSLPPA TGGSAPNPAT TTAASSSSSS SSSSSSSSSS ASSSSSSSSS SPPPASPPAS
SPPRVLELPG VPAAAFSDVL NFIYSARLAL PGGGGDGAAV AEIGALGRRL GISRLQGLGE
GGDAWVPPTP APMATSQPEE DSFGPRPRPA GEWEGDRAEA QAPDLQCSLP RRPLPCPQCG
KSFIHPKRLQ THEAQCRRGA STRGSTGLGA GGAGPGGPAG VDASALPPPA GFRGGPEHVV
KVVGGHVLYV CAACERSYVT LSSLKRHSNV HSWRRKYPCR YCEKVFALAE YRTKHEVWHT
GERRYQCIFC WETFVTYYNL KTHQRAFHGI SPGLLASEKT PNGGYKPKLN TLKLYRLLPM
RAAKRPYKTY SQGAPEAPLS PSLNTPAPVA MPASPPPGPP PAPEPGPPPS VITFAHPAPS
VIVHGGSSSG GGGSGTASTG GSQAASVITY TAPPRPPKKR EYPPPPPEPA ATPTSPATAA
SPATAAGPAT ATATEEAKGR NPRAGRTLTY TAKPVGGIGG GGGAPAGAGR GPSQLQAPPP
LCQITVRIGE EAIVKRRISE TDLRPGELSG EEMEETEDDE EEEDEEEEED EEESKAGGED
QLWRPYYSYK PKRKAGAAGG ASAGGSGPPR GRRPPRWRQK LERRSWEETP AAESPAGRAR
TERRHRCGDC AQTFATLRKL RKHQEAHGGG SHSSRAGRRP STRFTCPHCA KVCKTAAALS
RHGQRHAAER PGGTPTPVIA YSKGSAGTRP GDVKEEAPQE MQVSSSSGEA GGGSTAAEEA
SETASLQDPV ISGGEEPPVV AGGGSYAYPP VQEFPLALIG GGREPGGGRG KSGSEGPVGA
GEGDRMEGIG AAKVTFYPEP YPLVYGPQLL AAYPYNFSNL AALPVALNMV LPDEKGGGAL
PFLPGVFGYA VNPQAAPPTP PTPPPPTLPP PVPPKGEGER AGVERTQKGD VG
//
