ID A0A0D9RHF7_CHLSB Unreviewed; 1219 AA.
AC A0A0D9RHF7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=AP-3 complex subunit delta {ECO:0000256|PIRNR:PIRNR037092};
GN Name=AP3D1 {ECO:0000313|Ensembl:ENSCSAP00000008046.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008046.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008046.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008046.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane.
CC {ECO:0000256|PIRNR:PIRNR037092}.
CC -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer.
CC {ECO:0000256|PIRNR:PIRNR037092}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|PIRNR:PIRNR037092}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR037092}.
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DR EMBL; AQIB01150341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01150342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01150343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01150344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01150345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01150346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01150347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RHF7; -.
DR STRING; 60711.ENSCSAP00000008046; -.
DR Ensembl; ENSCSAT00000009940.1; ENSCSAP00000008046.1; ENSCSAG00000011851.1.
DR eggNOG; KOG1059; Eukaryota.
DR GeneTree; ENSGT00550000075067; -.
DR OMA; EQQNNPH; -.
DR Proteomes; UP000029965; Chromosome 6.
DR Bgee; ENSCSAG00000011851; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0098830; C:presynaptic endosome; IEA:Ensembl.
DR GO; GO:0043195; C:terminal bouton; IEA:Ensembl.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; IEA:Ensembl.
DR GO; GO:0048007; P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib; IEA:Ensembl.
DR GO; GO:0035646; P:endosome to melanosome transport; IEA:Ensembl.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IEA:Ensembl.
DR GO; GO:0051138; P:positive regulation of NK T cell differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0072657; P:protein localization to membrane; IEA:Ensembl.
DR GO; GO:0016182; P:synaptic vesicle budding from endosome; IEA:Ensembl.
DR GO; GO:0048499; P:synaptic vesicle membrane organization; IEA:Ensembl.
DR GO; GO:0140916; P:zinc ion import into lysosome; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.450.50; Longin domain; 1.
DR InterPro; IPR017105; AP3_complex_dsu.
DR InterPro; IPR010474; AP3D_dom_metazoa.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR22781:SF12; AP-3 COMPLEX SUBUNIT DELTA-1; 1.
DR PANTHER; PTHR22781; DELTA ADAPTIN-RELATED; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF06375; AP3D1; 1.
DR PIRSF; PIRSF037092; AP3_complex_delta; 1.
DR SMART; SM01354; BLVR; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037092};
KW Protein transport {ECO:0000256|PIRNR:PIRNR037092};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transport {ECO:0000256|PIRNR:PIRNR037092}.
FT DOMAIN 660..807
FT /note="AP-3 complex subunit delta"
FT /evidence="ECO:0000259|SMART:SM01354"
FT REGION 629..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..754
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..952
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1219 AA; 137127 MW; 5B04BE978BAF2081 CRC64;
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE
VLYAAAWICG EFSEHLQEPH HTLEAMLRPK VTTLPGHIQA VYVQNVVKLY ANILQQKEQA
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNAETSKSP EKDVPMVEKK
SKKPKKKEKK HKEKERDKEK KQQKEKKVKL VPRAEDLDFW LSTTPPPAPA PAPAPSTEEL
SVNAATTPKD ECEDAKTEAQ AEEDNAEGQD QDKKSPKHKK KKHKKEKEER TKGKKKSKKQ
PLGSEEAAGE PVQNGAPEEE PLPPESSYSL LAENSYVKMT CDIRGSLQED SQVTVAIVLE
NRSSSILKGM ELSVLDSLNA RMARPQGSSV HDGVPVPFQL PPGVSNEAQY VFTIQSIVMA
QKLKGTLSFI AKNDEGATHE KLDFRLHFSC SSYLTTTPCY SDAFAKLLES GDLSMSSVKV
DGIRMSFQNL LAKICFHHHF SVVERVDSCA SMYSRSIQGH HICLLVKKGE NSVSVDGKCS
DSTLLSNLLE EMKATLAKC
//
