ID A0A0D9RI98_CHLSB Unreviewed; 877 AA.
AC A0A0D9RI98;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=G protein-coupled receptor 158 {ECO:0000313|Ensembl:ENSCSAP00000008337.1};
GN Name=GPR158 {ECO:0000313|Ensembl:ENSCSAP00000008337.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008337.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008337.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008337.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; AQIB01160462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01160463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01160464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01160465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RI98; -.
DR STRING; 60711.ENSCSAP00000008337; -.
DR Ensembl; ENSCSAT00000010240.1; ENSCSAP00000008337.1; ENSCSAG00000012152.1.
DR eggNOG; KOG4418; Eukaryota.
DR GeneTree; ENSGT00940000155918; -.
DR OMA; THVCLPC; -.
DR Proteomes; UP000029965; Chromosome 9.
DR Bgee; ENSCSAG00000012152; Expressed in caudate nucleus and 4 other cell types or tissues.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR GO; GO:0160079; F:G protein-coupled glycine receptor activity; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050807; P:regulation of synapse organization; IEA:Ensembl.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF11; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 78..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..329
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 420..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 98321 MW; CDCC66330BCB4A0D CRC64;
MPIKGLGFVL GAYECICKAG FYHPGVLPVN NFRRRGPDQH ISGSTKDVSE EAYVCLPCRE
GCPFCADDSP CFVQEDKYLR LAIISFQALC MLLDFVSMLV VYHFRKAKSI RASGLILLET
ILFGSLLLYF PVVILYFEPS TFRCILLRWV RLLGFATVYG TVTLKLHRVL KVFLSRTAQR
IPYMTGGRVM RMLAVILLVV FWFLIGWTSS VCQNLEKQIS LIGQGQTSDH LIFNMCLIDR
WDYMTAVAEF LFLLWGVYLC YAVRTVPSAF HEPRYMAVAV HNELIISAIF HTIRFVLASR
LQSDWMLMLY FAHTHLTVTV TIGLLLIPKF SHSSNNPRDD IATEAYEDEL DMGRSGSYLN
SSINSAWSEH SLDPEDIRDE LKKLYAQLEI YKRKKMITNN PHLQKKRCSK KGLGRSIMRR
ITEIPETVSR QCSKEDKEGT DHGTAKGTAL IRKNPPESSG NTGKSKEENL KNRVFSLKKS
HSTYDHVRDQ TEESSSLPTE SQEEEVTENS TLESLSSKKL TQKLKEDSEA ESTESVPLVC
KSASAHNLSS EKKPGHSRTS MLQKSLSVIA SAKEKTLGLA GKTQTAGVEE SSKSQKPLPK
DKETNRNHSN SDNTETKDPT PQNSNPAEEP RKPQKSGIMK QQRVNPTTAN SDLNPGATQM
KDNFDIGEVC PWEVYDLTPG PVPSESKVQK HVSIVASEME KNPTFSLKEK SHHKPKAAEV
CQQSNQKRTD KAEVCLWRSQ GQSILEDEKH FISKTPVLPE RAKEENGGQL HAANVCAGQS
EELPPKAVAS KTENENLNQI GHQEKKTSSE EYVRGSYNSS NNFQQPLTSR AEVCPWEFET
PAQPNAGRSV ALPAASALSA NKIAGPRKEE VWDTFKV
//
