ID A0A0D9RIH6_CHLSB Unreviewed; 832 AA.
AC A0A0D9RIH6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Transmembrane protein 63B {ECO:0000313|Ensembl:ENSCSAP00000008415.1};
GN Name=TMEM63B {ECO:0000313|Ensembl:ENSCSAP00000008415.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008415.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008415.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008415.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; AQIB01160002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007970613.1; XM_007972422.1.
DR RefSeq; XP_007970614.1; XM_007972423.1.
DR RefSeq; XP_007970615.1; XM_007972424.1.
DR RefSeq; XP_007970616.1; XM_007972425.1.
DR AlphaFoldDB; A0A0D9RIH6; -.
DR SMR; A0A0D9RIH6; -.
DR STRING; 60711.ENSCSAP00000008415; -.
DR Ensembl; ENSCSAT00000010320.1; ENSCSAP00000008415.1; ENSCSAG00000012227.1.
DR GeneID; 103221440; -.
DR KEGG; csab:103221440; -.
DR CTD; 55362; -.
DR eggNOG; KOG1134; Eukaryota.
DR GeneTree; ENSGT00940000157084; -.
DR OMA; GKGFFAW; -.
DR OrthoDB; 231434at2759; -.
DR BioGRID-ORCS; 103221440; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 17.
DR Bgee; ENSCSAG00000012227; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:Ensembl.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:Ensembl.
DR GO; GO:1990760; F:osmolarity-sensing monoatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF38; CSC1-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 43..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..224
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 240..422
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 433..705
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 780..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 94934 MW; 8CE436D8720E4A62 CRC64;
MLPFLLATLG TTALNNSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM CFLALLFLFS
ILRKVAWDYG RLALVTDADR LRRQERDRVE QEYVASAMHG DSHDRYERLT SVSSSVDFDQ
RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG
DLLENNAYSF GRTTIANLKS GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR
TLFINGISKY AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN
LQSKENVPTM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QKLKEDYKRE KEKVNEKPLG
MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRPSSCSE SLHISNWTVS YAPDPQNIYW
EHLSIRGFIW WLRCLVINVV LFILLFFLTT PAIIITTMDK FNVTKPVEYL NNPIITQFFP
TLLLWCFSAL LPTIVYYSAF FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF
FRWLFDKKFL AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL
ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM YMLLKHLVDR
YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST MRTGFLAPTS MFTFVVLVIT
IVICLCHVCF GHFKYLSAHN YKIEHTETDT VDPRSNGRPS TAAAVPKSAK YIAQVLQDSE
VDGDGDGAPG SSGDEPPSSS SQDEELLMPP DGLTDTDFQS CEDSLIENEI HQ
//
