ID A0A0D9RJ26_CHLSB Unreviewed; 297 AA.
AC A0A0D9RJ26;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Transmembrane protein 178A {ECO:0000256|ARBA:ARBA00040063};
GN Name=TMEM178A {ECO:0000313|Ensembl:ENSCSAP00000008615.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008615.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008615.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008615.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM178 family.
CC {ECO:0000256|ARBA:ARBA00008199}.
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DR EMBL; AQIB01036985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01036994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007969056.1; XM_007970865.1.
DR AlphaFoldDB; A0A0D9RJ26; -.
DR STRING; 60711.ENSCSAP00000008615; -.
DR Ensembl; ENSCSAT00000010522.1; ENSCSAP00000008615.1; ENSCSAG00000012426.1.
DR GeneID; 103220436; -.
DR KEGG; csab:103220436; -.
DR CTD; 130733; -.
DR eggNOG; ENOG502R2WV; Eukaryota.
DR GeneTree; ENSGT00390000015299; -.
DR OMA; ATYAGLW; -.
DR OrthoDB; 5362939at2759; -.
DR BioGRID-ORCS; 103220436; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000012426; Expressed in Ammon's horn and 3 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR039625; T178A/B.
DR PANTHER; PTHR32005:SF4; TRANSMEMBRANE PROTEIN 178A; 1.
DR PANTHER; PTHR32005; TRANSMEMBRANE PROTEIN 178B-RELATED; 1.
DR Pfam; PF13903; Claudin_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 41..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 33019 MW; 757C5C9F7F2CFA53 CRC64;
MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA DPPDQKNRLM
PLSHLPLRDS PPLGRRLLPG GPGRADPESW RSLLGLGGLD AECGRPLFAT YSGLWRKCYF
LGIDRDIDTL ILKGIAQRCT AIKYHFSQPI RLRNIPFNLT KTIQQDEWHL LHLRRITAGF
LGMAVAVLLC GCIVATVSFF WEESLTQHVA GLLFLMTGIF CTISLCTYAA SISYDLNRLP
KLIYSLPADV EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAQLK SGRDSTV
//
