ID A0A0D9RJ41_CHLSB Unreviewed; 183 AA.
AC A0A0D9RJ41;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sorcin {ECO:0000313|Ensembl:ENSCSAP00000008630.1};
GN Name=SRI {ECO:0000313|Ensembl:ENSCSAP00000008630.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008630.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008630.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008630.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AQIB01018764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007980456.1; XM_007982265.1.
DR AlphaFoldDB; A0A0D9RJ41; -.
DR STRING; 60711.ENSCSAP00000008630; -.
DR Ensembl; ENSCSAT00000010537.1; ENSCSAP00000008630.1; ENSCSAG00000012443.1.
DR eggNOG; KOG0037; Eukaryota.
DR GeneTree; ENSGT00940000153979; -.
DR OMA; EGHEMQQ; -.
DR OrthoDB; 318691at2759; -.
DR BioGRID-ORCS; 103226599; 1 hit in 16 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 21.
DR Bgee; ENSCSAG00000012443; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0042584; C:chromaffin granule membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0055118; P:negative regulation of cardiac muscle contraction; IEA:Ensembl.
DR GO; GO:0010459; P:negative regulation of heart rate; IEA:Ensembl.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Ensembl.
DR GO; GO:1901844; P:regulation of cell communication by electrical coupling involved in cardiac conduction; IEA:Ensembl.
DR GO; GO:1901077; P:regulation of relaxation of muscle; IEA:Ensembl.
DR CDD; cd16187; EFh_PEF_sorcin; 1.
DR Gene3D; 6.10.140.900; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR46735; CALPAIN, SMALL SUBUNIT 1 A-RELATED; 1.
DR PANTHER; PTHR46735:SF7; SORCIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 85..120
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 183 AA; 20372 MW; 9DDF8D858E42A6F2 CRC64;
MQYGGAPGGP AFPGQTQDPL YGYFAAVAGQ DGQIDADELQ RCLTQSGIAG GYKPFNLETC
RLMVSMLDRD MSGKMGFNEF KELWAVLNGW RQHFISFDTD RSGTVDPQEL QKALTTMGFR
LSPQAVNSIA KRYSTNGKIT FDDYIACCVK LRALTDSFRR RDTAQQGVVN FPYDDFIQCV
MSV
//
