ID A0A0D9RJA7_CHLSB Unreviewed; 741 AA.
AC A0A0D9RJA7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Ribonuclease L {ECO:0000313|Ensembl:ENSCSAP00000008696.1};
GN Name=RNASEL {ECO:0000313|Ensembl:ENSCSAP00000008696.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008696.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008696.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008696.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01113009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007987466.1; XM_007989275.1.
DR AlphaFoldDB; A0A0D9RJA7; -.
DR STRING; 60711.ENSCSAP00000008696; -.
DR Ensembl; ENSCSAT00000010606.1; ENSCSAP00000008696.1; ENSCSAG00000012514.1.
DR GeneID; 103230468; -.
DR CTD; 6041; -.
DR eggNOG; KOG1027; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000161114; -.
DR OMA; YGSESHK; -.
DR OrthoDB; 2994922at2759; -.
DR BioGRID-ORCS; 103230468; 2 hits in 16 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 25.
DR Bgee; ENSCSAG00000012514; Expressed in blood and 4 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:Ensembl.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:Ensembl.
DR CDD; cd10423; RNase_RNase-L; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR042745; RNase-L_RNase.
DR PANTHER; PTHR24141; 2-5A-DEPENDENT RIBONUCLEASE; 1.
DR PANTHER; PTHR24141:SF1; 2-5A-DEPENDENT RIBONUCLEASE; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT REPEAT 24..56
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 58..90
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 91..123
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 124..156
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 167..200
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 201..237
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 365..586
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 589..723
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 83765 MW; B6D08B5BA6609F0B CRC64;
METRDHNNPQ EGPTSSSGRR ATVEDNHLLI KAVQTEDVDL VQQLLEGGAN VNFQEKEGGW
TPLHNAVQMD REDIVELLLR YDADPVLRKK NGATPFIVAA IVGNVKLLEL FLSKGADVNE
CDFYGFTAFM EAAVYGNVKA LKFLYERGAN VNLRRKTKED QERLRKGGAT ALMDAAKEGH
VEVLKILLDE MGADVNACDN MGRNALIHAL LSSHNRDVEA ITHLLLDHGA DVNVRGERGK
TPLILAVENK HLGLVKRLLK QEHIEINDTD SDGKTALLLA VELKLKDIAQ LLCDCGASTD
CGDLVMIARR NYDHSLVKLL LSHGAEEHFH PPAEDWKPQS SHWGAALKDL HRIYRPMIGK
LKFFIDEKYK IADTSEGGIY LGFYEKQEVA VKTFCEGSPR ARQEVSCLQS SRENSHLVTF
YGSESHRGHL FVCVTLCEQT LEACLEVHRG EDVENEEDEF ARNVLSSIFK AVQELHLSCA
YTHQDLQPQN ILIDSKNAVH LADFDKSIKW TGDPQEVKRD LEDLGRLVLY VVKKGSISFE
ELKAQSNEEV VQLSPDEETK DLIHHLFHPG EHVRDCLGDL LGHPFFWTWE SRYRTLRNVG
NESDIKTRKH KSEILKLLQP GPSEHSVSFD KWTTKINADV MKKMNEFYKK SGNFYQNTVG
DLLKFIRNLG EHIDEEKHKK MKLKIGDPSP YFQKTFPDLV IYVYTKLQNT EYRKHFPQTH
SSNKPQCDGA GGTSRLASPG C
//
