ID A0A0D9RJN2_CHLSB Unreviewed; 639 AA.
AC A0A0D9RJN2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=CD2 associated protein {ECO:0000313|Ensembl:ENSCSAP00000008821.1};
GN Name=CD2AP {ECO:0000313|Ensembl:ENSCSAP00000008821.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008821.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008821.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008821.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01160035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01160036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01160037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007970513.1; XM_007972322.1.
DR AlphaFoldDB; A0A0D9RJN2; -.
DR STRING; 60711.ENSCSAP00000008821; -.
DR Ensembl; ENSCSAT00000010732.1; ENSCSAP00000008821.1; ENSCSAG00000012642.1.
DR GeneID; 103221401; -.
DR CTD; 23607; -.
DR eggNOG; KOG4348; Eukaryota.
DR GeneTree; ENSGT00940000157566; -.
DR OMA; XEIKRET; -.
DR OrthoDB; 2972088at2759; -.
DR BioGRID-ORCS; 103221401; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 17.
DR Bgee; ENSCSAG00000012642; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0001771; P:immunological synapse formation; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0032911; P:negative regulation of transforming growth factor beta1 production; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0071559; P:response to transforming growth factor beta; IEA:Ensembl.
DR GO; GO:0051403; P:stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032905; P:transforming growth factor beta1 production; IEA:Ensembl.
DR CDD; cd12053; SH3_CD2AP_1; 1.
DR CDD; cd12054; SH3_CD2AP_2; 1.
DR CDD; cd12056; SH3_CD2AP_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR035775; CD2AP_SH3_1.
DR InterPro; IPR035777; CD2AP_SH3_3.
DR InterPro; IPR035776; CD2AP_SH_2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF92; CIN85 AND CD2AP RELATED, ISOFORM J; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..59
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 108..167
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 269..330
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 168..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 583..635
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 182..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 71269 MW; 2D6FD130CF910C59 CRC64;
MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE
TEFKDDSLPI KRERHGNVAS LVQRISTYGL PAGGIQPHPQ TKNIKKKTKK RQCKVLFEYI
PQNEDELELK VGDIIDINEE VEEGWWSGTL NNKLGLFPSN FVKELEVTDD GETREAQDDS
ETVLGGPTSP LPSPGNGSET APGSITQPKK IRGIGFGDIF KEGSVKLRTR TSSSETEEKK
PEKPLILPSL GSKTQSMEIT KTDSEGKIKA KEYCRTLFAY EGSNEDELTF KEGEIIHLIS
KETGEAGWWK GELNGKEGVF PDNFAVQINE LDKDLPKPKK PPPPAKAPAP KPEMIAAEKK
YFSLKPEEKD EKSTLEQKPS KPAAPQVPPK KPTPPTKANN LLRSSGTMYP KRPEKPVPPP
PPIAKINGEV STIASKFETE PVSKPKLDSE QLPLRPKSVD LDSLIVRTSK ETDVVNFDDI
ASSENLLHLT ANRPKMPGRR LPGRFNGGHS PTHSPEKILK LPKEEDSANL KPSELKKDTC
SSPKPSVYLS TPSSASKANT TAFLTPLEIK AKVETDDVKK NSLDELRAQI IELLCIVEAL
KKDHGKELEK LRKDLEEEKA MRSDLEMEIE KLKKAILSS
//
