ID A0A0D9RJN7_CHLSB Unreviewed; 575 AA.
AC A0A0D9RJN7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=WSC domain containing 1 {ECO:0000313|Ensembl:ENSCSAP00000008826.1};
GN Name=WSCD1 {ECO:0000313|Ensembl:ENSCSAP00000008826.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000008826.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000008826.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000008826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR EMBL; AQIB01138045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01138046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01138047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008008227.1; XM_008010036.1.
DR RefSeq; XP_008008228.1; XM_008010037.1.
DR AlphaFoldDB; A0A0D9RJN7; -.
DR STRING; 60711.ENSCSAP00000008826; -.
DR Ensembl; ENSCSAT00000010739.1; ENSCSAP00000008826.1; ENSCSAG00000012648.1.
DR GeneID; 103242246; -.
DR KEGG; csab:103242246; -.
DR CTD; 23302; -.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000158096; -.
DR OMA; KDFEPFT; -.
DR OrthoDB; 3971278at2759; -.
DR BioGRID-ORCS; 103242246; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000012648; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 142..234
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 245..340
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 575 AA; 65696 MW; 84D4D92137A176FC CRC64;
MAKPFFRLQK FLRRTQFLLF FLTAAYLMTG SLLLLQRARV ALPQGPRAPG PLQTLPVAAV
ALGVGLLDSR ALHDPRVSPE LLLGVDMLQS PLTRPRPGPR WLRSRNSELR QLRRRWFHHF
MSDSQGPPAL GPEAPRPAIH SRGTYVGCFS DDGHERTLKG AVFYDLRKMT VSHCQDACAE
RSYVYAGLEA GAECYCGNRL PATSVGLEEC SHECKGEKGS VCGAVDRLSV YRVDELQPGS
RKRRTATYRG CFRLPDNITH AFPSSLIQAN VTVETCSGFC SQKEFPLAIL RGWECYCAYP
TPQFNLRDAM DNSLCGQDPE AQKLAEYCEV YQTPVQDTRC TDRRFLPNKS KVFVALSSFP
GAGNTWARHL IEHATGFYTG SYYFDGTLYN KGFKGEKDHW RSRRTICVKT HESGRREIEM
FDSAILLIRN PYRSLVAEFN RKCAGHLGYA ADRNWKSKEW PDFVNSYASW WSSHVLDWLK
YGKRLLVVHY EELRRSLVPT LREMVAFLNV SVSEERLLCV ENNKEGSFRR RGRRSHDPEP
FTPEMKDLIN GYIRTVDKAL RDHNWTGLPR EYVPR
//
