ID A0A0D9RKG4_CHLSB Unreviewed; 651 AA.
AC A0A0D9RKG4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=ATP binding cassette subfamily G member 5 {ECO:0000313|Ensembl:ENSCSAP00000009103.1};
GN Name=ABCG5 {ECO:0000313|Ensembl:ENSCSAP00000009103.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000009103.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000009103.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000009103.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily.
CC {ECO:0000256|ARBA:ARBA00005814}.
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DR EMBL; AQIB01038041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007968977.1; XM_007970786.1.
DR AlphaFoldDB; A0A0D9RKG4; -.
DR STRING; 60711.ENSCSAP00000009103; -.
DR Ensembl; ENSCSAT00000011019.1; ENSCSAP00000009103.1; ENSCSAG00000012947.1.
DR GeneID; 103220380; -.
DR KEGG; csab:103220380; -.
DR CTD; 64240; -.
DR eggNOG; KOG0061; Eukaryota.
DR GeneTree; ENSGT00940000157985; -.
DR OMA; RVRPWWD; -.
DR OrthoDB; 936137at2759; -.
DR BioGRID-ORCS; 103220380; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000012947; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0045796; P:negative regulation of intestinal cholesterol absorption; IEA:Ensembl.
DR GO; GO:0010949; P:negative regulation of intestinal phytosterol absorption; IEA:Ensembl.
DR CDD; cd03234; ABCG_White; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR PANTHER; PTHR48041:SF113; ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 390..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..293
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 72733 MW; A7DAA7613B48518B CRC64;
MGDLSSLTPG GSTGLQVNRG SQSSLEGAPA TALKPHSLGI LHASYSVSHR VRPWWDITSC
RQQWTRQILN DVSLYVESGQ IMCILGSSGS GKTTLLDAMS GRLRRTGTFL GEVYVNGRAL
RREQFQDCFS YVLQNDTLLS SLTVRETLRY TALLAIRCGN PGFFQKKVEA IMAELSLSHV
ADRLIGNYNL GGISTGERRR VSIAAQLLQD PKVMLFDEPT TGLDCMTANQ IVILLVELAR
RNRIVVLTIH QPRSELFQLF DKIAILSFGE LIFCGTPVEM LDFFSDCGYP CPEHSNPFDF
YMDLTSVDTQ SKEREIETYK RVQMIESAYK KSAICHKTLE NIERTKHLKT LPMVPFKTKD
SPGVFSKLGV LLRRVTRNLV RNKLAVMMRL LQNLTMGLFL LFFVLRVQNN VLKGAIQDRV
GLLYMFVGST PYTGMLNAVN LFPVLRAVSD QESQDGLYQK WQMLLAYVLH VLPFSVVATM
IFSSVCYWTL GLHPEVARFG YFSAAVLAPH LIGEFLTLVL LGIIQNPNIV NSVVALLSIA
GVLVGSGLVR NIQEMPTPFK IISYFTFQKY CSEILLVNEF YGLNFTCGSS NVSVATNPMC
AFTQGIQFIE ETSPGATSRF TMNFLILYSF IPALVILGIV VFKIRDHLIS R
//
