ID A0A0D9RM75_CHLSB Unreviewed; 1359 AA.
AC A0A0D9RM75;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Complement factor H {ECO:0000313|Ensembl:ENSCSAP00000009714.1};
GN Name=CFH {ECO:0000313|Ensembl:ENSCSAP00000009714.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000009714.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000009714.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000009714.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AQIB01112818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01112819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01112820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01112821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01112822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000009714; -.
DR Ensembl; ENSCSAT00000011648.1; ENSCSAP00000009714.1; ENSCSAG00000013551.1.
DR eggNOG; ENOG502QVSB; Eukaryota.
DR GeneTree; ENSGT00940000163274; -.
DR OMA; TNNIPIC; -.
DR Proteomes; UP000029965; Chromosome 25.
DR Bgee; ENSCSAG00000013551; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:1905370; C:serine-type endopeptidase complex; IEA:Ensembl.
DR GO; GO:0106139; C:symbiont cell surface; IEA:Ensembl.
DR GO; GO:0043395; F:heparan sulfate proteoglycan binding; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0006956; P:complement activation; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR GO; GO:0030451; P:regulation of complement activation, alternative pathway; IEA:Ensembl.
DR GO; GO:1903659; P:regulation of complement-dependent cytotoxicity; IEA:Ensembl.
DR CDD; cd00033; CCP; 15.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 22.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45785:SF7; COMPLEMENT FACTOR H; 1.
DR PANTHER; PTHR45785; COMPLEMENT FACTOR H-RELATED; 1.
DR Pfam; PF00084; Sushi; 21.
DR SMART; SM00032; CCP; 22.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 20.
DR PROSITE; PS50923; SUSHI; 17.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1359
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002345287"
FT DOMAIN 19..82
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 83..143
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 144..207
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 208..264
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 265..322
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 387..444
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 446..507
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 567..625
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 628..686
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 689..746
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 809..866
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 868..928
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 929..986
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 987..1045
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1046..1104
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1169..1226
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1231..1289
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 114..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 178..205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 630..673
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 989..1032
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1048..1091
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1233..1276
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1359 AA; 153705 MW; D5A67A640B84AAA1 CRC64;
MKLLAKIICL MLWAICVAED CKELPPRKNT EILTGSWPDS TYPEGTPAIY KCRPGYRSLG
NIVMVCRKGE WVAVNPLKKC QKRPCGHPGD TPFGYFSLIG GNVFEYGVKA VYTCNEGYQL
LGEINYRECD ADGWTNDIPI CEVVKCLPVK PPENGKIISG AMEADREYHF GQVVRFACNS
GYKIEGDNEM HCSEGGVWSK EKPKCVEISC KSPDVIHGSP ISQKIIYKEN ERFQYKCNMG
YEYSERGDSV CTESGWHPLP SCEEKTCNVP YIPNGVYSPL RIKHRTGDEI RYQCINGFYP
ATRGNTAKCT STGWIPAPRC SLRPCDFPNI KHGELYYENM RRPYFPVPVG KYFSYRCDES
FETPSGSYWN YIHCTQDGWS PAVPCLRKCY FPYLENGYND NSGRKFVQGN AIEVACHRGY
SLPKEQTTVT CTENGWSPTP RCIRVKTCSK SSIDIKNGFI SESQYTYALN EQAKYQCKLG
YITADGETSG SITCRKNGWS AQPTCIKSCD MPVFKNARAK NNITWFKLNY TLDYECHDGY
ESNTGSTTGS IVCGDNGWSD LPVCYERECE LPKIDVHLVP DPKKDQYKVG EVLKFSCKLG
FTRVGPNSVQ CYHFGLSPDL PTCKEQVQSC GPPPELLNGN VKEKMKEEYR HSEVVEYYCN
PRFLLKGPNK IQCVDGAWTT LPVCIEEEST CGDIPELEHG YFELSSPPYY YGDSVEFNCS
ESFTMIGHRS ITCIHGVWTQ LPQCVATDQL KKCKSPNSIV IVENLTNKKE FDHNSTMRYR
CRGKGGRLHA VCINGRWDPE VTCSMAQIKL CPPPPQIPNS WTMKTTLNYR DGEKVSVLCQ
ENYLIQEGEE MMCKDGRWQS IPRCVEKIPC TQPPHVEHGS IISSRSSQEN YAHGTKLSYT
CEDGFRLSKE NEITCYMGKW SSPPHCEGLP CKSPPEISHG VVAHTSDSYQ YGEEVTYKCS
EGFGIDGPPI TKCLGEKWSH PPSCIKTDCL SLPSFENAIL MGEKKDSYKS GEQVTYTCAT
NYKMDGPSTV TCINSRWTGR PTCRDTSCAD PPTVKNAHIV SRQMSKYASG ERVRYECRSP
YEMFGDEEVM CVNGNWTEPP QCKVRPCHFP DIKHGSLYYE NMRRPYFPVP VGKYFSYHCD
ESFETSSGSY WDYIHCTQDG WSPAVPCLRK CYFPYLVNGY NDNNGRKFVQ GNSIEVACHP
GYGLPNEQTT VNCTENGWSP PLRCIRVNSA RKCGPPPPID NGDITSFPLS LYAPDSSVEY
QCQNLYQLEG NKRVTCRNGQ WSEPPKCLHA CLISPAILEK YNITLKWKAE EKLYSRTGEP
VEFVCRSGYR LSPNSHALRT TCQDGKLEYP TCVKRHHRS
//
