ID A0A0D9RNK9_CHLSB Unreviewed; 1201 AA.
AC A0A0D9RNK9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=CD109 molecule {ECO:0000313|Ensembl:ENSCSAP00000010198.1};
GN Name=CD109 {ECO:0000313|Ensembl:ENSCSAP00000010198.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000010198.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000010198.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000010198.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR EMBL; AQIB01133011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01133016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RNK9; -.
DR STRING; 60711.ENSCSAP00000010198; -.
DR Ensembl; ENSCSAT00000012152.1; ENSCSAP00000010198.1; ENSCSAG00000014064.1.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000155926; -.
DR OMA; EVHIYFE; -.
DR Proteomes; UP000029965; Chromosome 17.
DR Bgee; ENSCSAG00000014064; Expressed in fibroblast and 5 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0061045; P:negative regulation of wound healing; IEA:Ensembl.
DR GO; GO:0072675; P:osteoclast fusion; IEA:Ensembl.
DR GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF162; CD109 ANTIGEN; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT DOMAIN 224..355
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 449..540
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1067..1151
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1201 AA; 134309 MW; E400BBA3248C81D0 CRC64;
MNSKHLNGTI VAKYTYGKPV KGDVTLTFLP LSFWGKKKNI TKTFKINGSV NFSFNDEEMK
NIMDSSNGLD VASPGPVEIL ATVTESLTGI ARNASTNVFF KQHDYIIEFF DYTTVLKPSL
NFTATVKVTR ADGNQLTLEE RRNNVVIAVT QGNCTECWSG SNSGNQKMET VQKINYTVPQ
NGTFKIGFPI LEDSSELQLK AYFLGSKSSI AVHSMFKSPS KTYIQLKTRD ENIKVGSPFE
LVVSGNKRLK ELSYMVVSRG QLVAVGKQNS TIFSLTPENS WTPKACVIVY YIEDDGEIIN
DVLKIPVQLV FKNKIKLYWS KVKAEPSEKV SLRMSVTQPD SIAGIVAVDK TVNLMYASND
LTMENVVHEL ELYNTGYYLG MFMNSFAVFQ ECGLWVLTDA NLTKDYIDGV YDNAEYAEKF
MEENEGHVVD IQDFSLGSSP HVRKHFPETW IWLDTNMGSR IYQEFEVTVP DSITSWVATG
FVISEDLGLG LTKTPVELQA FQPFFIFLNL PYSVIRGEEF ALEITIFNYL KDTTEVKVII
EKSDKFDILM TSSEINATGH QQTILVPSED GATVLFPIRP THLGEIPITV TALSPTASDA
ITQMILVKAE GIEKSYSQSI LLDLTDNRLQ STLKTLSFSF PPNTVTGSER VQITAIGDVL
GPSINGLASL IRMPYGCGEQ NMIHFAPNIY ILDYLTKKKQ LTDNLKEKAL SFMRQGYQRE
LLYQREDGSF SAFGNYDASG STWLSAFVLR CFLEADPYID IDQNVLHRTY TWLKERQKSN
GEFWEPGKVI HSELQGGNKS PVTLTAYIVT SLLGYRKYQP NIDVQESIHF LESEFSRGIS
DNYTLALIAY ALSSVGSPKA KEALNMLTSR AEQEGGMQFW VSSESKLSDS WQPRSLDIEV
AAYALLSHFL QFQASEGIPI MRWLSRQRNS LGGFASTQDT IVALKALSEF AALMITERTN
IQVTVMGPSA PSPIKFLIDT HNRLLLQTAE LAVVQPTAVN ISANGFGFAI CQLNVVYNVK
DSGSSRRRRS IQNQEAFDLD VAVKENKDDL NHVDLNVCTR FLGPARSGMA LMEVNLLSGF
MVPSDTIPLS ETVKKVEYDH GKLNLYLDSV NETQFCVDIP AVRNFKVSNT QDASVSIVDY
YEPRRQAVRS YNSEAKLSSC DLCSDVQGCR PCEDGAVGSH HHPSVIFIFC FMLLYFLELW
P
//
