ID A0A0D9RNQ3_CHLSB Unreviewed; 619 AA.
AC A0A0D9RNQ3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00026121};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
DE AltName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00041297};
GN Name=SLC27A6 {ECO:0000313|Ensembl:ENSCSAP00000010242.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000010242.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000010242.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000010242.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate +
CC tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:65052, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036436};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640;
CC Evidence={ECO:0000256|ARBA:ARBA00036436};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain
CC fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036527};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537;
CC Evidence={ECO:0000256|ARBA:ARBA00036527};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; AQIB01044056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01044057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01044058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008012501.1; XM_008014310.1.
DR AlphaFoldDB; A0A0D9RNQ3; -.
DR STRING; 60711.ENSCSAP00000010242; -.
DR Ensembl; ENSCSAT00000012196.1; ENSCSAP00000010242.1; ENSCSAG00000014106.1.
DR GeneID; 103244474; -.
DR KEGG; csab:103244474; -.
DR CTD; 28965; -.
DR eggNOG; KOG1179; Eukaryota.
DR GeneTree; ENSGT00940000159700; -.
DR OMA; VWRQFLD; -.
DR OrthoDB; 1650656at2759; -.
DR BioGRID-ORCS; 103244474; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 23.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IEA:Ensembl.
DR GO; GO:0015908; P:fatty acid transport; IEA:UniProt.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05938; hsFATP2a_ACSVL_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR43107:SF10; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 6; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 62..372
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 499..571
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 619 AA; 70123 MW; E7C28C323405F1F9 CRC64;
MLLSWLTVLG AGMVVLHFVQ KLLFPYFWDD FLFLVKVLLV IIRLKKYEKR GELVTVLDKF
LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS SLKKGDTVAL LMSNEPDFVH
VWFGLAKLGC VVAFLNSNIR SNSLLNCIRA CGPTALVVGA DLLGTVEEIL PSLSENISVW
GMKDSVPQGI ISLKEKLSTS SDEPVPRSRH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ
VLRGSAVLWA FGCTADDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWNDC
KKYDVTVFQY IGELCRYLCK QSKREGERDH KVRLAIGNGM RSDVWREFLD RFGNIKVCEL
YAATESNISF MNYTGKIGAI GRANFFHKLL STFDLIKYDF QKDEPMRNEQ GWCIHVKKGE
PGLLISRVHA KNPFFGYAGP YKHTKDKLLC DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT
GDTFRWKGEN VSTTEVVDVI GMLDFIQETN VYGVAISGYE GRAGMASIIL KPNKSLDLEK
VYEQVVTSLP AYACPRFLRI QEKMEATGTF KLLKYRLVEE GFNPLKISEP LYFMDNLKKS
YVPLTRELYD QIMLGEIKL
//
