ID A0A0D9RNX7_CHLSB Unreviewed; 934 AA.
AC A0A0D9RNX7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Integrin subunit alpha 9 {ECO:0000313|Ensembl:ENSCSAP00000010316.1};
GN Name=ITGA9 {ECO:0000313|Ensembl:ENSCSAP00000010316.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000010316.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000010316.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000010316.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AQIB01119303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01119304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01119305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007969967.1; XM_007971776.1.
DR AlphaFoldDB; A0A0D9RNX7; -.
DR STRING; 60711.ENSCSAP00000010316; -.
DR Ensembl; ENSCSAT00000012274.1; ENSCSAP00000010316.1; ENSCSAG00000014176.1.
DR GeneID; 103221076; -.
DR CTD; 3680; -.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000156503; -.
DR OMA; MMRKGMA; -.
DR OrthoDB; 3816176at2759; -.
DR BioGRID-ORCS; 103221076; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 15.
DR Bgee; ENSCSAG00000014176; Expressed in adrenal cortex and 4 other cell types or tissues.
DR GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR GO; GO:0034679; C:integrin alpha9-beta1 complex; IEA:Ensembl.
DR GO; GO:0098640; F:integrin binding involved in cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045906; P:negative regulation of vasoconstriction; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF69; INTEGRIN ALPHA-9; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 877..901
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 189..248
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 250..307
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 312..373
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 358..517
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 519..663
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 671..866
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 934 AA; 103624 MW; 0E69DAB79A200385 CRC64;
MARGKNRGTS CGKTCREDRD DEWMGVSLAR QPKADGRVLA CAHRWKNVYY EADHILPHGF
CYIIPSNLQA KGRTLIPCYE EYKKKYGEEH GSCQAGIAGF FTEELVVMGA PGSFYWAGTI
KVLNLTDNTY LKLNDEVIMN RRYTYLGYAV TAGHFSHAST TDVVGGAPQD KGIGKVYIFR
ADRRSGTLIK IFQASGKKMG SYFGSSLCAV DLNGDGLSDL LVGAPMFSEI RDEGQVTVYI
NRGNGALEEQ LALTGDGAYN AHFGESIASL DDLDDDGFPD VAIGAPKEDD FAGAVYIYHG
DASGIVPQYS MKLSGRKINP VLRMFGQSIS GGIDMDGNGY PDVTVGAFMS DSVVLLRARP
VITMDVAIFL PGSINITAPQ CHDGQQPVNC LNVTTCFSFR GKHVPGEIGL NYVLTADVAK
KEKGQLPRVY FVLLGETVGQ VTEKLQLTYM EETCRHYVAH VKRRVQDVIS PIVFEAAYSL
GEHVTGEEER ELPPLTPVLR WKKGQKIAQK NQTVFERNCH SEDCAADLQL RGKLLLSSMD
EKTLYLALGA VKNISLNISI SNLGDDAYDA NVSFNVSREL FFINMWQKEE MGISCELLES
DFLKCSVGFP FMRSKSKYEF SVIFDTSHLS GEEEVLSFIV TAQSGNMERS ESLHDNTLVL
MVPLMHEVDT SITGIMSPTS FVYGESVDAA NFIQLDDLEC HFQPINITLQ VYNTGPSTLP
GSSVSISFPN RLSSGGAEMF HVQEMVVGQE KGNCSFQKNP TPCIIPQEQE NIFHTIFAFF
TKSGRKVLDC EKPGISCLTA HCNFSALAKE ESRTIDIYML LNTEILKKDS SSVIQFMSRA
KVKVDPALRV VEIAHGNPEE VTVVFEALHN LEPRGYVVGW IIAISLLVGI LIFLLLAVLL
WKMGFFRRRY KEIIEAEKNR KENEDSWDWV QKNQ
//