UniProt: A0A0D9RQG8

Database: UniProt
Entry: A0A0D9RQG8_CHLSB

LinkDB:  A0A0D9RQG8_CHLSB 
Original site:  A0A0D9RQG8_CHLSB

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Ontology (4)   
   GO (4)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (6)   
   EMBL (6)   
Protein domain (8)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
All databases (24)   

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ID   A0A0D9RQG8_CHLSB        Unreviewed;       710 AA.
AC   A0A0D9RQG8;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Prolyl endopeptidase {ECO:0000256|ARBA:ARBA00016310, ECO:0000256|RuleBase:RU368024};
DE            EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
GN   Name=PREP {ECO:0000313|Ensembl:ENSCSAP00000010857.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000010857.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000010857.1, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000010857.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR   EMBL; AQIB01069842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01069843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01069844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01069845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01069846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIB01069847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008005659.1; XM_008007468.1.
DR   AlphaFoldDB; A0A0D9RQG8; -.
DR   STRING; 60711.ENSCSAP00000010857; -.
DR   Ensembl; ENSCSAT00000012835.1; ENSCSAP00000010857.1; ENSCSAG00000014741.1.
DR   GeneID; 103240656; -.
DR   KEGG; csab:103240656; -.
DR   CTD; 5550; -.
DR   eggNOG; KOG2237; Eukaryota.
DR   GeneTree; ENSGT00530000063426; -.
DR   OMA; LDPWFSH; -.
DR   OrthoDB; 7264at2759; -.
DR   BioGRID-ORCS; 103240656; 1 hit in 16 CRISPR screens.
DR   Proteomes; UP000029965; Chromosome 13.
DR   Bgee; ENSCSAG00000014741; Expressed in fibroblast and 7 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368024};
KW   Protease {ECO:0000256|RuleBase:RU368024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Serine protease {ECO:0000256|RuleBase:RU368024}.
FT   DOMAIN          7..422
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          484..705
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   710 AA;  80766 MW;  C9C049288E451474 CRC64;
     MLSLQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR
     GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGDA RVFLDPNILS
     DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFSCMAWTH
     DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL YYHVLGTDQS EDILCAEFPD EPKWMGGAEL
     SDDGRYVLLS IREGCDPVNR LWYCDLQQES NGITGILKWV KLIDNFEGEY DYVTNEGTVF
     TFKTNRHSPN YRVINIDFRD PEESKWKVLV PEHEKDVLEW VACVRSNFLV LCYLHDVKNI
     LQLHDLTTGA LLKTFPLEVG SIVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR
     VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI
     TPNYSVSRLI FVRHMGGILA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE
     GYTSPKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG
     CSDSKQHFEW LVKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV
     GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNIDWIP
//

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