ID A0A0D9RR66_CHLSB Unreviewed; 176 AA.
AC A0A0D9RR66;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Interleukin family protein {ECO:0000256|RuleBase:RU368043};
GN Name=IL20 {ECO:0000313|Ensembl:ENSCSAP00000011105.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000011105.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000011105.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000011105.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Immune regulatory cytokine. {ECO:0000256|RuleBase:RU368043}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368043}.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC {ECO:0000256|ARBA:ARBA00008813, ECO:0000256|RuleBase:RU368043}.
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DR EMBL; AQIB01112667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007986852.1; XM_007988661.1.
DR RefSeq; XP_007986853.1; XM_007988662.1.
DR AlphaFoldDB; A0A0D9RR66; -.
DR STRING; 60711.ENSCSAP00000011105; -.
DR Ensembl; ENSCSAT00000013093.1; ENSCSAP00000011105.1; ENSCSAG00000015003.1.
DR GeneID; 103230189; -.
DR KEGG; csab:103230189; -.
DR CTD; 50604; -.
DR eggNOG; ENOG502S5RZ; Eukaryota.
DR GeneTree; ENSGT00950000183124; -.
DR OMA; LQATESC; -.
DR OrthoDB; 5347451at2759; -.
DR BioGRID-ORCS; 103230189; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 25.
DR Bgee; ENSCSAG00000015003; Expressed in fibroblast and 1 other cell type or tissue.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045517; F:interleukin-20 receptor binding; IEA:Ensembl.
DR GO; GO:0045518; F:interleukin-22 receptor binding; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020423; IL-10_CS.
DR InterPro; IPR020442; IL-20.
DR PANTHER; PTHR48394; INTERLEUKIN-19-RELATED; 1.
DR PANTHER; PTHR48394:SF4; INTERLEUKIN-20; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01935; INTRLEUKIN20.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368043};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR620443-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368043};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU368043}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT CHAIN 25..176
FT /note="Interleukin family protein"
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT /id="PRO_5031604990"
FT DISULFID 33..126
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 80..132
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 81..134
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
SQ SEQUENCE 176 AA; 20129 MW; EF156BBA2E0831A8 CRC64;
MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR GRVQAKDGNI
DIRILRRTES LQDTKPADRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK
KDLRLCHAHM TCHCGEEAMK KYGQILSHFE ELELQAAVVK ALGELDILLQ WMEETE
//
