ID A0A0D9RR75_CHLSB Unreviewed; 569 AA.
AC A0A0D9RR75;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1 {ECO:0000256|ARBA:ARBA00015260};
GN Name=EEPD1 {ECO:0000313|Ensembl:ENSCSAP00000011114.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000011114.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000011114.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000011114.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01018252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01018253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01018254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007979809.1; XM_007981618.1.
DR AlphaFoldDB; A0A0D9RR75; -.
DR STRING; 60711.ENSCSAP00000011114; -.
DR Ensembl; ENSCSAT00000013103.1; ENSCSAP00000011114.1; ENSCSAG00000015009.1.
DR GeneID; 103226223; -.
DR KEGG; csab:103226223; -.
DR eggNOG; KOG1857; Eukaryota.
DR GeneTree; ENSGT00390000009677; -.
DR OMA; HLVPANT; -.
DR OrthoDB; 3037349at2759; -.
DR BioGRID-ORCS; 103226223; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 21.
DR Bgee; ENSCSAG00000015009; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl.
DR CDD; cd10283; MnuA_DNase1-like; 1.
DR Gene3D; 1.10.150.280; AF1531-like domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 1.10.150.320; Photosystem II 12 kDa extrinsic protein; 1.
DR InterPro; IPR004509; Competence_ComEA_HhH.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR NCBIfam; TIGR00426; competence protein ComEA helix-hairpin-helix repeat region; 1.
DR PANTHER; PTHR21180; ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21180:SF32; ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF12836; HHH_3; 2.
DR SMART; SM00278; HhH1; 3.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 48..67
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 78..97
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 145..164
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT REGION 365..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 62510 MW; 2392DC9B69B6B028 CRC64;
MGSTLGCHRS IPRDPSDLSH NRKFSAACNF SNILVNQERL NINTATEEEL MTLPGVTRAV
ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV SSKGSSTQHS PSSLRRDLLA
EQQPHHLATA VPLTPRVNIN TATPAQLMSV RGLSEKMALS IVDFRREHGP FRSVEDLVRM
DGINAAFLDR IRHQVFAERS RPPSTHTNGG LTFIAKPHPS PTSLSLQSED LDLPPGGPTQ
IISTRPSVEA FGGTRDGRPV LRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
ELLDREALEK FCTELNQPTL PNMRKWKGPR GCWKAVVAEK PSNQLQKGAG YAGFLWDAAA
GVELRDAGSQ ESSPSNGHGK PAGPSPYLAR FKVGSHDLTL VNLHLAALTL PGSENFSKNH
SDGHRLASFA QTLQETLKGE KDVIILGDFG QGPDSSDYDI LRKEKFHHLI PTHTFTNIST
KNPQGSKPLD NIWISKSLKK VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAELYT
EKEWSKKDAP RNGSGVALER SEANIKHER
//
