ID A0A0D9RUU8_CHLSB Unreviewed; 366 AA.
AC A0A0D9RUU8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Left-right determination factor {ECO:0000256|PIRNR:PIRNR037402};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012387.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000012387.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000012387.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037402}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037402,
CC ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AQIB01130297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007986466.1; XM_007988275.1.
DR AlphaFoldDB; A0A0D9RUU8; -.
DR STRING; 60711.ENSCSAP00000012387; -.
DR Ensembl; ENSCSAT00000014413.1; ENSCSAP00000012387.1; ENSCSAG00000016323.1.
DR KEGG; csab:103229999; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00390000010056; -.
DR OMA; SCAWDGV; -.
DR OrthoDB; 5391376at2759; -.
DR BioGRID-ORCS; 103229999; 2 hits in 14 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 25.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR003942; LRDF.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF226; LEFT-RIGHT DETERMINATION FACTOR; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF037402; TGFb4; 1.
DR PRINTS; PR01427; TGFBETA4.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|PIRNR:PIRNR037402};
KW Developmental protein {ECO:0000256|PIRNR:PIRNR037402};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037402};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037402};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..366
FT /note="Left-right determination factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002345662"
FT DOMAIN 240..354
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 366 AA; 40709 MW; A8E917D667330080 CRC64;
MRPLWLCWAL WVLPLAGPGV AMTGEQLLGS LLQQLQLSEV PVPDRVDMEE LVIPAHVRAQ
YVALLRRSHG DRSRGKRFSH SFREVAGRFL ASEASTHLLV FGMEQRLPPN SELVQAVLRL
FQEPVPKAAL HRHGRLSPRS ARARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKVFDV
TEAVNFWQQL SRPRPPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL
DLRDYGAQGD CDPEATVTEG TRCCRQEMYI DLQGMKWADN WVLEPPGFLA YECVGTCQQP
PEALAVKWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMKVQK CSCASDGALV
PRILQP
//
