ID A0A0D9RVG2_CHLSB Unreviewed; 3147 AA.
AC A0A0D9RVG2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Laminin subunit alpha 2 {ECO:0000313|Ensembl:ENSCSAP00000012601.1};
GN Name=LAMA2 {ECO:0000313|Ensembl:ENSCSAP00000012601.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012601.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000012601.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000012601.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; AQIB01065432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01065441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000012601; -.
DR Ensembl; ENSCSAT00000014636.1; ENSCSAP00000012601.1; ENSCSAG00000016545.1.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000155362; -.
DR OMA; SHSRINF; -.
DR Proteomes; UP000029965; Chromosome 13.
DR Bgee; ENSCSAG00000016545; Expressed in adrenal cortex and 5 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:Ensembl.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 16.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF291; LAMININ SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 16.
DR Pfam; PF00054; Laminin_G_1; 4.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00180; EGF_Lam; 17.
DR SMART; SM00281; LamB; 2.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS01248; EGF_LAM_1; 6.
DR PROSITE; PS50027; EGF_LAM_2; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..222
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 350..404
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 405..453
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 474..659
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 693..742
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 743..800
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 801..853
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 854..907
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 991..1037
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1038..1083
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1084..1129
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1130..1189
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1204..1403
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1444..1492
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1551..1597
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2170..2353
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2365..2546
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2551..2735
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2788..2959
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2964..3144
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1706..1858
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2005..2032
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2058..2165
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 350..362
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 380..389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 424..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 712..721
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 771..780
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 825..834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 837..851
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 854..866
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 856..873
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 875..884
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 991..1003
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1011..1020
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1056..1065
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1084..1096
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1086..1103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1105..1114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1130..1142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1160..1169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1463..1472
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1551..1563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1553..1570
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1572..1581
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2708..2735
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 3147 AA; 347412 MW; 31737068A8D7E626 CRC64;
MYCKLVEHVP GQPVRNPQCR ICNQNSSNPN QRHPITNAID GKNTWWQSPS IKNGIEYHYV
TITLDLQQVF QIAYVIVKAA NSPRPGNWIL ERSLDDVEYK PWQYHAVTDT ECLTLYNIYP
RTGPPSYAKD DEVICTSFYS KIHPLENGEI HISLINGRPS ADDPSPELLE FTSARYIRLR
FQRIRTLNAD LMMFAHKDPR EIDPIVTRRY YYSVKDISVG GMCICYGHAR ACPLDPATNK
SRCECEHNTC GDSCDQCCPG FHQKPWRAGT FLTKTECEAC NCHGKAEECY YDENVARRSL
SLNIHGKYIG GGVCINCTQN TAGINCETCI DGFFRPKGVS PNYPRPCQPC HCNPIGSLNE
VCVKDEKHAR RGLAPGSCHC KTGFGGVSCD RCARGYTGYP DCKACNCSGL GSKNEDPCFG
PCNCKENVEG GDCSRCKSGF FNLQEDNWKG CDECFCSGVS NRCQSSYWTY GKIQDMSGWY
LTDLSGRIRV APQQDDSDSP QQISISNAEA RQALSHSYYW SAPAPYLGNK LPAVGGQLTF
TISYDLEEEE EDTEHVLQFM IILEGNDLRI STAQDEVYLH PSEEHVNVLL LKEESFTIHG
THFPVSRKEF MTVLANLKRV LLQITYSFGM DAIFRLSSVN LESAVSYPTD GSVAAAVEVC
QCPPGYTGSS CESCWPRHRR INGTIFGGIC EPCQCFGHAE SCDDVTGECL NCKDHTGGPY
CDKCLPGFYG DPTKGTSEDC QPCACPLNIP SNNFSPTCHL DRSLGLICDG CPVGYTGPRC
ERCAEGYFGQ PSVPGGSCQP CQCNDNLDFS IPGSCDSLSG SCLICKPGTT GRYCELCADG
YFGDAVDARN CQPCRCNANG SFSEICHSQT GQCECRANVQ GQRCDKCKPN MWWDPEKRFC
VLCDCDPVGS VSPQCDITGR CVCKSDFVGK QCNLGRQVHQ QEEQPRRAQR VLGSPQRWAI
GSSSGCPRGA YRAPAPPGTF GLQSARGCVP CNCNSFGSKS FDCEESGQCW CQPGVTGKKC
DRCAHGYFNF QEGGCTACEC SHLGNNCDPK TGRCICPPNT IGEKCSKCTP NTWGHSITTG
CKACNCSIVG SLDFQCNVNT GQCNCHPKFS GAKCTECSRG HWNYPRCNLC DCFLPGTDAA
TCDSETKKCS CSDQTGQCTC KVNVEGIHCD RCQPGKFGLD AKNPLGCSSC YCFGATTQCS
EAKGLIWTWV TLKAEQTILP LVDEALQHTT TKGIVFQHPE IVAHMDLMRE DLHWEPFYWK
LPEQFEGKKL MAYGGKLKYA IYFEAREETG FSTYNPQVII RGGTPTHARI IVRHMAAPLI
GQLTRHEIEM TEKEWKYYGD DPRVHRTVTR EDFLDILYDI HYILIKATYG NFMRQSRISE
ISMEVAEQGR RTAVTPPAHL IEKCDCPLGY SGLSCEACLP GFYRLRSQPG GRTPGPTLGT
CVPCQCNGHS SLCDPETSIC QNCQHHTAGD FCERCALGYY GIVKGLPNDC QQCACPLISS
SNNFSPSCVT EGLDDYRCTA CPRGYEGQYC ERCAPGYTGS PSSPGGSCQE CECDPYGSLP
VPCDPVTGIC TCRPGATGRK CDGCKRWHAR EGWECVFCGD ECTGLLLGDL ARLEQMVMSI
NLSGPLPAPY KMLYGLENTT QELKHLLSPQ RAPERLIQLA EGNLNTLVTE MNELLTRATK
VTADGEQTGQ DAERTNTRAK SLGEFIKELA RDAEAVNEKA IKLNETLGTR DEAFERNLEG
LQKEIDQMIK ELRRKNLETQ KEIAEDELVA AEGLLKKVKK LFGESRGKNE EMEKDLREKL
ADYKNKVDDA WDLLREATNK IREANRLFAV NQRNMTALEK KKEAVESGKR QIENTLKEGD
DILDEANRLA DEINSIIDYV EDIQTKLPPM SEELNNKIDD LSQEIKDRKL AEKVSQAESH
AAQLNDSSAV LDGILDEAKN ISFNATAAFK AYSNIKDYID EAEKVAKEAK DLAHEATKLA
TGPRGLLKED AKGSLQKSFR ILNEAKKLAN DVKENEDHLN GLKTRIENAD ARNGDLLRAL
NDTLGKLSAI PNDTAAKLQA VKDKARQAND TAKDVLAQIK ELHQNLDGLK KNYDKLADSV
AKTNAVVKDP SKNSKIFADA DATVKNLEQE ADRLIDKLKP IKELEDNLKK NISEIKELIN
QARKQANSIK VSVSSGGDCI RTYKPEIKKG SYNNIVINVK TAVADNLLFY LGSAKFIDFL
AIEMRKGKVS FLWDVGSGVG RVEYPDLTID DSYWYRIMAS RTGRNGTISV RALDGPKASI
VPSTYHSTSP PGYTILDVDA NAMLFVGGLT GKLKKADAVR VITFTGCMGE TYFDNKPIGL
WNFREKEGDC KGCTVSPQVE DSEGTIQFDG EGYALVSRPI RWYPNISTVM FKFRTFSSSA
LLMYLATRDL RDFMSVELTD GHVKVSYDLG SGMASVVSNQ NHNDGKWKSF TLSRIQKQAN
ISIVDIDTNQ EENIATSSSG NNFGLDLKAD DKIYFGGLPT LRNLSMKARP EVNLKKYSGC
LKDIEISRTP YNILSSPDYV GVTKGCSLEN VYTVSFPKPG FVELSPVPID VGTEINLSFS
TKNESGIILL GSGGTPAPPR RKRRQTGQAY YAILLNRGRL EVHLSTGART MRKIVVRPEP
NLFHDGREHS VHVERTRGIF TVQADENRRY MQNLTVEQPL EVKKLFVGGA PPEFQPSPLR
NIPPFEGCVW NLVINSVPMD FARPVSFKNA DIGRCVHQKL HEDEDGAAPA EIVIQPEPVP
TPAFPTPTPV LTHGPCAAES EPALLIGSKQ FGLSRNSHIA IAFDDTKVKN RLTIELEVRT
EAESGLLFYM ARINHADFAT VQLRNGLPYF SYDLGSGDTN TMIPTKINDG QWHKIKIMRS
KQEGILYVDG ASNRTISPRK ADILDVVGML YVGGLPVNYT TRRIGPVTYS IAGCIRNLHM
AEAPADLEEP TSSFHVGTCF ANAQRGTYFD GTGFAEAVGG FKVGLDLLVE FEFRTTRTTG
VLLGISSQKM DGMGIEMIDE KLMFHVDNGA GRFTAVYDAG VPGHLCDGQW HKVTANKIKH
RIELTVDGNQ VEAQSLNPAS TSADTNDPVF VGGFPDDLKQ FGLTTSIPFR GCIRSLKLTK
GTGKPLEVNF AKALELRGVQ PVSCPAN
//
